Literature DB >> 12827035

Delayed sodium channel inactivation mimics long QT syndrome 3.

Volker Kühlkamp1, Christian Mewis, Ralph Bosch, Ludger Seipel.   

Abstract

DPI 201-106 delays sodium channel inactivation. Acute administration of DPI 201-106 prolonged the QT interval, provoked spontaneous torsades de pointes in one patient, and facilitated stimulation-induced polymorphic ventricular tachyarrhythmias in two patients. Similar to the observations in animal studies, delaying sodium channel inactivation is a new form of the acquired long QT syndrome, mimicking long QT syndrome type 3.

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Year:  2003        PMID： 12827035     DOI： 10.1097/00005344-200307000-00017

Source DB:  PubMed          Journal:  J Cardiovasc Pharmacol        ISSN： 0160-2446            Impact factor:   3.105


  6 in total

Review 1.  Drug-induced long QT syndrome.

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Review 2.  Cardiac applications for human pluripotent stem cells.

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Journal:  Curr Pharm Des       Date:  2009       Impact factor: 3.116

3.  The angiotensin receptor blocker and PPAR-γ agonist, telmisartan, delays inactivation of voltage-gated sodium channel in rat heart: novel mechanism of drug action.

Authors:  Hyoung Kyu Kim; Jae Boum Youm; Sung Ryul Lee; Se Eun Lim; Sun-Young Lee; Tae Hee Ko; Le Thanh Long; Bernd Nilius; Du Nam Won; Jung-Hyun Noh; Kyung Soo Ko; Byoung Doo Rhee; Nari Kim; Jin Han
Journal:  Pflugers Arch       Date:  2012-10-17       Impact factor: 3.657

Review 4.  Long QT syndrome: beyond the causal mutation.

Authors:  Ahmad S Amin; Yigal M Pinto; Arthur A M Wilde
Journal:  J Physiol       Date:  2013-06-10       Impact factor: 5.182

5.  Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice.

Authors:  John S Lowe; Dina Myers Stroud; Tao Yang; Lynn Hall; Thomas C Atack; Dan M Roden
Journal:  Cardiovasc Res       Date:  2012-05-04       Impact factor: 10.787

Review 6.  Cellular basis of drug-induced torsades de pointes.

Authors:  D M Roden
Journal:  Br J Pharmacol       Date:  2008-06-16       Impact factor: 8.739
  6 in total

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