Literature DB >> 1282701

hnRNP A2/B1 binds specifically to single stranded vertebrate telomeric repeat TTAGGGn.

S J McKay1, H Cooke.   

Abstract

We have previously isolated a protein from mouse liver nuclei that specifically binds to single stranded (TTAGGG)n repeats. TTAGGG is the telomeric repeats of mammals and we therefore named the new protein single stranded telomere binding protein (sTBP). Further studies now identify sTBP as heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 on the basis of amino acid sequence determination and antibody reactivity. A2 and B1 form a major part of the protein component of hnRNP particles and are abundant nuclear proteins. Unexpectedly, A2/B1 has a high specificity for binding to the RNA equivalent of TTAGGG, UUAGGG, but under the same conditions does not appear to have a strong affinity for a number of other RNA species.

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Year:  1992        PMID： 1282701      PMCID： PMC334558          DOI： 10.1093/nar/20.24.6461

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  16 in total

1.  Renaturation of complementary DNA strands mediated by purified mammalian heterogeneous nuclear ribonucleoprotein A1 protein: implications for a mechanism for rapid molecular assembly.

Authors:  B W Pontius; P Berg
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

2.  A protein which specifically binds to single stranded TTAGGGn repeats.

Authors:  S J McKay; H Cooke
Journal:  Nucleic Acids Res       Date:  1992-03-25       Impact factor: 16.971

3.  Identification and characterization of the packaging proteins of core 40S hnRNP particles.

Authors:  A L Beyer; M E Christensen; B W Walker; W M LeStourgeon
Journal:  Cell       Date:  1977-05       Impact factor: 41.582

4.  Conservation of the human telomere sequence (TTAGGG)n among vertebrates.

Authors:  J Meyne; R L Ratliff; R K Moyzis
Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

Review 5.  Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation.

Authors:  G Dreyfuss; M S Swanson; S Piñol-Roma
Journal:  Trends Biochem Sci       Date:  1988-03       Impact factor: 13.807

6.  Modulation of hnRNP A1 protein gene expression by epidermal growth factor in Rat-1 cells.

Authors:  S R Planck; M D Listerud; S D Buckley
Journal:  Nucleic Acids Res       Date:  1988-12-23       Impact factor: 16.971

7.  Chromatin structure of the molecular ends of Oxytricha macronuclear DNA: phased nucleosomes and a telomeric complex.

Authors:  D E Gottschling; T R Cech
Journal:  Cell       Date:  1984-09       Impact factor: 41.582

8.  The core proteins of 35S hnRNP complexes. Characterization of nine different species.

Authors:  H E Wilk; H Werr; D Friedrich; H H Kiltz; K P Schäfer
Journal:  Eur J Biochem       Date:  1985-01-02

9.  Higher order DNA structure in macronuclear chromatin of the hypotrichous ciliate Oxytricha nova.

Authors:  H J Lipps; W Gruissem; D M Prescott
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

10.  All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3' terminus.

Authors:  L A Klobutcher; M T Swanton; P Donini; D M Prescott
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205
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  46 in total

1.  Identification of two human nuclear proteins that recognise the cytosine-rich strand of human telomeres in vitro.

Authors:  L Lacroix; H Liénard; E Labourier; M Djavaheri-Mergny; J Lacoste; H Leffers; J Tazi; C Hélène; J L Mergny
Journal:  Nucleic Acids Res       Date:  2000-04-01       Impact factor: 16.971

2.  Telomere-binding and Stn1p-interacting activities are required for the essential function of Saccharomyces cerevisiae Cdc13p.

Authors:  M J Wang; Y C Lin; T L Pang; J M Lee; C C Chou; J J Lin
Journal:  Nucleic Acids Res       Date:  2000-12-01       Impact factor: 16.971

3.  hnRNP A1 associates with telomere ends and stimulates telomerase activity.

Authors:  Qing-Shuo Zhang; Lisa Manche; Rui-Ming Xu; Adrian R Krainer
Journal:  RNA       Date:  2006-04-07       Impact factor: 4.942

4.  macroH2A1 histone variants are depleted on active genes but concentrated on the inactive X chromosome.

Authors:  Lakshmi N Changolkar; John R Pehrson
Journal:  Mol Cell Biol       Date:  2006-06       Impact factor: 4.272

5.  Anti-A2/RA33 autoantibodies are directed to the RNA binding region of the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. Differential epitope recognition in rheumatoid arthritis, systemic lupus erythematosus, and mixed connective tissue disease.

Authors:  K Skriner; W H Sommergruber; V Tremmel; I Fischer; A Barta; J S Smolen; G Steiner
Journal:  J Clin Invest       Date:  1997-07-01       Impact factor: 14.808

Review 6.  Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics.

Authors:  Manti Guha; Narayan G Avadhani
Journal:  Mitochondrion       Date:  2013-09-01       Impact factor: 4.160

7.  Establishment of a new method, transcription-reverse transcription concerted reaction, for detection of plasma hnRNP B1 mRNA, a biomarker of lung cancer.

Authors:  Akemi Sato; Naoko Sueoka-Aragane; Juichi Saitoh; Kazutoshi Komiya; Takashi Hisatomi; Rika Tomimasu; Shinichiro Hayashi; Eisaburo Sueoka
Journal:  J Cancer Res Clin Oncol       Date:  2008-05-07       Impact factor: 4.553

8.  Isolation and characterization of two Saccharomyces cerevisiae genes that encode proteins that bind to (TG1-3)n single strand telomeric DNA in vitro.

Authors:  J J Lin; V A Zakian
Journal:  Nucleic Acids Res       Date:  1994-11-25       Impact factor: 16.971

9.  Distinct domains in the CArG-box binding factor A destabilize tetraplex forms of the fragile X expanded sequence d(CGG)n.

Authors:  Pnina Weisman-Shomer; Esther Cohen; Michael Fry
Journal:  Nucleic Acids Res       Date:  2002-09-01       Impact factor: 16.971

10.  Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n.

Authors:  F Ishikawa; M J Matunis; G Dreyfuss; T R Cech
Journal:  Mol Cell Biol       Date:  1993-07       Impact factor: 4.272
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