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Literature DB >> 12825833

Epibatidine: impact on nicotinic receptor research.

Abstract

Epibatidine is a natural product that was isolated and identified by Daly and coworkers in 1992. Since that time, it has had a profound influence on the investigation of alpha4beta2 nicotinic cholinergic (nACh) receptor pharmacophore models, and has inspired the development of novel agents with therapeutic potential in CNS disorders. Apart from acetylcholine and nicotine, probably no other agent has had as much recent impact on nACh research as has epibatidine.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2003 PMID： 12825833 DOI： 10.1023/a:1023692705700

Source DB: PubMed Journal: Cell Mol Neurobiol ISSN： 0272-4340 Impact factor: 5.046

40 in total

Review 1. The pharmacological basis of contemporary pain management.

Authors: R D MacPherson
Journal: Pharmacol Ther Date: 2000-11 Impact factor: 12.310

Review 2. Therapeutic potential of neuronal nicotinic acetylcholine receptor agonists as novel analgesics.

Authors: M W Decker; M D Meyer
Journal: Biochem Pharmacol Date: 1999-09-15 Impact factor: 5.858

3. Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2'-substituted 5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Epibatidine analogues.

Authors: F I Carroll; F Liang; H A Navarro; L E Brieaddy; P Abraham; M I Damaj; B R Martin
Journal: J Med Chem Date: 2001-06-21 Impact factor: 7.446

Review 4. Nicotinic acetylcholine receptors and imaging.

Authors: D Gündisch
Journal: Curr Pharm Des Date: 2000-07 Impact factor: 3.116

5. Improving the nicotinic pharmacophore with a series of (Isoxazole)methylene-1-azacyclic compounds: synthesis, structure-activity relationship, and molecular modeling.

Authors: J E Tønder; J B Hansen; M Begtrup; I Pettersson; K Rimvall; B Christensen; U Ehrbar; P H Olesen
Journal: J Med Chem Date: 1999-12-02 Impact factor: 7.446

6. 2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling.

Authors: A O Koren; A G Horti; A G Mukhin; D Gündisch; A S Kimes; R F Dannals; E D London
Journal: J Med Chem Date: 1998-09-10 Impact factor: 7.446

7. Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2'-substituted-3'-phenyl-5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Novel nicotinic antagonist.

Authors: F I Carroll; J R Lee; H A Navarro; L E Brieaddy; P Abraham; M I Damaj; B R Martin
Journal: J Med Chem Date: 2001-11-22 Impact factor: 7.446

8. Fluoro-norchloroepibatidine: preclinical assessment of acute toxicity.

Authors: P E Molina; Y S Ding; F I Carroll; F Liang; N D Volkow; N Pappas; M Kuhar; N Abumrad; S J Gatley; J S Fowler
Journal: Nucl Med Biol Date: 1997-11 Impact factor: 2.408

9. Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.

Authors: Christopher G V Sharples; Gunter Karig; Graham L Simpson; James A Spencer; Emma Wright; Neil S Millar; Susan Wonnacott; Timothy Gallagher
Journal: J Med Chem Date: 2002-07-18 Impact factor: 7.446

10. Synthesis and biological evaluation at nicotinic acetylcholine receptors of N-arylalkyl- and N-aryl-7-azabicyclo[2.2.1]heptanes.

Authors: Jie Cheng; Chunming Zhang; Edwin D Stevens; Sari Izenwasser; Dean Wade; Shaoyi Chen; Dennis Paul; Mark L Trudell
Journal: J Med Chem Date: 2002-07-04 Impact factor: 7.446

7 in total

1. Phantasmidine: an epibatidine congener from the ecuadorian poison frog Epipedobates anthonyi.

Authors: Richard W Fitch; Thomas F Spande; H Martin Garraffo; Herman J C Yeh; John W Daly
Journal: J Nat Prod Date: 2010-03-26 Impact factor: 4.050

2. Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats.

Authors: Lisa C Loram; Jacqueline A Harrison; Lindsey Chao; Frederick R Taylor; Anireddy Reddy; Carissa L Travis; Rona Giffard; Yousef Al-Abed; Kevin Tracey; Steven F Maier; Linda R Watkins
Journal: Brain Behav Immun Date: 2010-03-28 Impact factor: 7.217