AIMS: Intrauterine exposure to tobacco smoke products has been associated with long-term neurobehavioral effects. Modified appetite control might explain the recently observed association between maternal smoking during pregnancy and obesity in offspring. METHODS: Some 10,557 British adults aged 42 years born between 3-9 March 1958 were followed up in a birth cohort study (NCDS). The main outcome measure was self-reported poor appetite at age 42 years and main exposure was maternal smoking during pregnancy. RESULTS: The proportion of offspring with poor appetite increased with maternal smoking during pregnancy: non-smoking 4.5%; (4.0%-5.0%), medium smoking 5.6%; (4.5%-6.8%), variable smoking 6.8%; (4.9%-9.1%) and heavy smoking 7.7%; (6.3%-9.4%). The unadjusted odds ratios for maternal smoking during pregnancy (ever/never) and poor appetite is 1.49 (1.25-1.77) and after adjustment for BMI at 42 years and other potential confounding factors it is 1.22 (1.01-1.48). CONCLUSIONS: Offspring of mothers who smoked during pregnancy were more likely to report a poor appetite independent of a number of potential confounding factors. Although not in the expected direction, the results suggest maternal smoking during pregnancy may influence appetite perception through a developmental influence or through confounding by social factors.
AIMS: Intrauterine exposure to tobacco smoke products has been associated with long-term neurobehavioral effects. Modified appetite control might explain the recently observed association between maternal smoking during pregnancy and obesity in offspring. METHODS: Some 10,557 British adults aged 42 years born between 3-9 March 1958 were followed up in a birth cohort study (NCDS). The main outcome measure was self-reported poor appetite at age 42 years and main exposure was maternal smoking during pregnancy. RESULTS: The proportion of offspring with poor appetite increased with maternal smoking during pregnancy: non-smoking 4.5%; (4.0%-5.0%), medium smoking 5.6%; (4.5%-6.8%), variable smoking 6.8%; (4.9%-9.1%) and heavy smoking 7.7%; (6.3%-9.4%). The unadjusted odds ratios for maternal smoking during pregnancy (ever/never) and poor appetite is 1.49 (1.25-1.77) and after adjustment for BMI at 42 years and other potential confounding factors it is 1.22 (1.01-1.48). CONCLUSIONS: Offspring of mothers who smoked during pregnancy were more likely to report a poor appetite independent of a number of potential confounding factors. Although not in the expected direction, the results suggest maternal smoking during pregnancy may influence appetite perception through a developmental influence or through confounding by social factors.
Authors: Andreas Beyerlein; Simon Rückinger; André Michael Toschke; Angelika Schaffrath Rosario; Rüdiger von Kries Journal: Eur J Epidemiol Date: 2011-03-01 Impact factor: 8.082
Authors: Joe M Braun; Julie L Daniels; Charles Poole; Andrew F Olshan; Richard Hornung; John T Bernert; Jane Khoury; Larry L Needham; Dana B Barr; Bruce P Lanphear Journal: Paediatr Perinat Epidemiol Date: 2010-08-16 Impact factor: 3.980
Authors: Sherry Zhou; David G Rosenthal; Scott Sherman; Judith Zelikoff; Terry Gordon; Michael Weitzman Journal: Curr Probl Pediatr Adolesc Health Care Date: 2014-06-25