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Literature DB >> 12824914

Regulation of TGF-beta signaling and its roles in progression of tumors.

Kohei Miyazono¹, Hiroyuki Suzuki, Takeshi Imamura.

Abstract

Transforming growth factor-beta (TGF-beta) is a potent growth inhibitor of most types of cells; therefore, perturbations of TGF-beta signaling are believed to result in progression of various tumors. On the other hand, TGF-beta has been shown to act as an oncogenic cytokine through induction of extracellular matrices, angiogenesis, and immune suppression. A wide variety of effects of TGF-beta are mediated by physical interaction of signal transducer Smad proteins with various transcription factors. Among these, Runx3 plays a pivotal role in prevention of gastric cancer. TGF-beta signaling is regulated by various mechanisms in the cytoplasm and nucleus. Inhibitory Smads (I-Smads) repress TGF-beta signaling mainly by interacting with activated TGF-beta receptors. Smad ubiquitin regulatory factors (Smurfs) play important roles in facilitating the inhibitory signals induced by I-Smads. In addition, the transcriptional co-repressors c-Ski and SnoN interact with Smads, and repress transcription induced by TGF-beta. Abnormalities of these regulators of TGF-beta signaling may thus participate in the progression of various tumors.

Entities: Disease Gene

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Year: 2003 PMID： 12824914 DOI： 10.1111/j.1349-7006.2003.tb01425.x

Source DB: PubMed Journal: Cancer Sci ISSN： 1347-9032 Impact factor: 6.716

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Cited

51 in total

1. Activin modulates the transcriptional response of LbetaT2 cells to gonadotropin-releasing hormone and alters cellular proliferation.

Authors: Hao Zhang; Janice S Bailey; Djurdjica Coss; Bo Lin; Rie Tsutsumi; Mark A Lawson; Pamela L Mellon; Nicholas J G Webster
Journal: Mol Endocrinol Date: 2006-06-13

2. Nicotine inhibits myofibroblast differentiation in human gingival fibroblasts.

Authors: Yiyu Fang; Kathy K H Svoboda
Journal: J Cell Biochem Date: 2005-08-15 Impact factor: 4.429

3. Application of RUNX3 gene promoter methylation in the diagnosis of non-small cell lung cancer.

Authors: Gui-Ping Yu; Yong Ji; Guo-Qiang Chen; Bin Huang; Kai Shen; Song Wu; Zhen-Ya Shen
Journal: Oncol Lett Date: 2011-10-19 Impact factor: 2.967

4. TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF.

Authors: Sang Soo Kim; Kirti Shetty; Varalakshmi Katuri; Krit Kitisin; Hye Jung Baek; Yi Tang; Blair Marshall; Lynt Johnson; Bibhuti Mishra; Lopa Mishra
Journal: Biochem Biophys Res Commun Date: 2006-04-19 Impact factor: 3.575

Regulation of TGF-beta signaling and its roles in progression of tumors.

1. Activin modulates the transcriptional response of LbetaT2 cells to gonadotropin-releasing hormone and alters cellular proliferation.

2. Nicotine inhibits myofibroblast differentiation in human gingival fibroblasts.

3. Application of RUNX3 gene promoter methylation in the diagnosis of non-small cell lung cancer.

4. TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF.

5. Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7.

6. Smad2 and Smad6 as predictors of overall survival in oral squamous cell carcinoma patients.

7. Induction of gastric cancer cell adhesion through transforming growth factor-beta1-mediated peritoneal fibrosis.

8. Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2.

9. Folliculostellate cells determine the susceptibility of lactotropes to estradiol's mitogenic action.

10. Pin1 promotes transforming growth factor-beta-induced migration and invasion.