Literature DB >> 1282485

The conformational specificity of viral epitopes.

M H Van Regenmortel1.   

Abstract

Four types of antigenic sites found in viruses are discussed: cryptotopes, neotopes, metatopes and neutralization epitopes. The role played by conformation on the specificity of viral epitopes is illustrated in the case of tobacco mosaic virus and influenza virus. It appears that mechanisms reminiscent of induced fit contribute to the recognition of viral epitopes by antibodies.

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Year:  1992        PMID： 1282485     DOI： 10.1111/j.1574-6968.1992.tb14081.x

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  8 in total

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Review 2.  What does it mean to develop an HIV vaccine by rational design?

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Review 5.  On the irrationality of rational design of an HIV vaccine in light of protein intrinsic disorder.

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6.  Increased antibodies against unfolded viral antigens in the elderly after influenza vaccination.

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Journal:  Influenza Other Respir Viruses       Date:  2007-07       Impact factor: 4.380

Review 7.  Structure-Based Reverse Vaccinology Failed in the Case of HIV Because it Disregarded Accepted Immunological Theory.

Authors:  Marc H V Van Regenmortel
Journal:  Int J Mol Sci       Date:  2016-09-21       Impact factor: 5.923

8.  Development of a Preventive HIV Vaccine Requires Solving Inverse Problems Which Is Unattainable by Rational Vaccine Design.

Authors:  Marc H V Van Regenmortel
Journal:  Front Immunol       Date:  2018-01-12       Impact factor: 7.561
  8 in total

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