Literature DB >> 12824039

Novel inhibitors of procollagen C-proteinase. Part 2: glutamic acid hydroxamates.

L A Robinson1, D M Wilson, N G J Delaet, E K Bradley, S M Dankwardt, J A Campbell, R L Martin, H E Van Wart, K A M Walker, R W Sullivan.   

Abstract

Glutamic acid derived hydroxamates were identified as potent and selective inhibitors of procollagen C-proteinase, an essential enzyme for the processing of procollagens to fibrillar collagens. Such compounds have potential therapeutic application in the treatment of fibrosis.

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Year:  2003        PMID： 12824039     DOI： 10.1016/s0960-894x(03)00402-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  The Scar-in-a-Jar: studying potential antifibrotic compounds from the epigenetic to extracellular level in a single well.

Authors:  C Z C Chen; Y X Peng; Z B Wang; P V Fish; J L Kaar; R R Koepsel; A J Russell; R R Lareu; M Raghunath
Journal:  Br J Pharmacol       Date:  2009-09-28       Impact factor: 8.739

2.  Ancylostoma caninum MTP-1, an astacin-like metalloprotease secreted by infective hookworm larvae, is involved in tissue migration.

Authors:  Angela L Williamson; Sara Lustigman; Yelena Oksov; Vehid Deumic; Jordan Plieskatt; Susana Mendez; Bin Zhan; Maria Elena Bottazzi; Peter J Hotez; Alex Loukas
Journal:  Infect Immun       Date:  2006-02       Impact factor: 3.441

3.  3-Hy-droxy-2-(4-meth-oxy-benzene-sulfonamido)-butanoic acid.

Authors:  Suman Sinha; Hasnah Osman; Habibah A Wahab; Madhukar Hemamalini; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-11-12
  3 in total

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