| Literature DB >> 12824014 |
Thomas A Engler1, Kelly Furness, Sushant Malhotra, Concha Sanchez-Martinez, Chuan Shih, Walter Xie, Guoxin Zhu, Xun Zhou, Scott Conner, Margaret M Faul, Kevin A Sullivan, Stanley P Kolis, Harold B Brooks, Bharvin Patel, Richard M Schultz, Tammy B DeHahn, Kashif Kirmani, Charles D Spencer, Scott A Watkins, Eileen L Considine, Jack A Dempsey, Catherine A Ogg, Nancy B Stamm, Bryan D Anderson, Robert M Campbell, Vasu Vasudevan, Michelle L Lytle.
Abstract
The synthesis and CDK inhibitory properties of a series of indolo[6,7-a]pyrrolo[3,4-c]carbazoles is reported. In addition to their potent CDK activity, the compounds display antiproliferative activity against two human cancer cell lines. These inhibitors also effect strong G1 arrest in these cell lines and inhibit Rb phosphorylation at Ser780 consistent with inhibition of cyclin D1/CDK4.Entities:
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Year: 2003 PMID： 12824014 DOI： 10.1016/s0960-894x(03)00461-x
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823