Literature DB >> 12822888

The KRAB domain of zinc finger gene ZNF268: a potential transcriptional repressor.

Yan Sun1, De-ming Gou, Hui Liu, Xiao Peng, Wen-xin Li.   

Abstract

Nearly one-third of Krupple-type C2H2 zinc finger proteins have a krupple-associated box (KRAB) domain, which may act as a transcriptional repressor. ZNF268, which was novelty isolated from early human embryo, is a typical krupple-type C2H2 zinc finger protein with a conserved KRAB domain. In this report, the KRAB domain of ZNF268 is identified to localize in the nucleus and has transcriptional repressor activity.

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Year:  2003        PMID： 12822888     DOI： 10.1080/1521654031000110208

Source DB:  PubMed          Journal:  IUBMB Life        ISSN： 1521-6543            Impact factor:   3.885


  8 in total

1.  Noncoding-RNA mediated high expression of zinc finger protein 268 suppresses clear cell renal cell carcinoma progression by promoting apoptosis and regulating immune cell infiltration.

Authors:  Keyi Wang; Yongzhe Gu; Jinliang Ni; Houliang Zhang; Yidi Wang; Yifan Zhang; Xianchao Sun; Tianyuan Xu; Weipu Mao; Bo Peng
Journal:  Bioengineered       Date:  2022-04       Impact factor: 6.832

2.  The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling.

Authors:  Wei Wang; Mingxiong Guo; Li Hu; Jinyang Cai; Yan Zeng; Jun Luo; Zhiqiang Shu; Wenxin Li; Zan Huang
Journal:  J Biol Chem       Date:  2012-10-22       Impact factor: 5.157

3.  Human T-cell leukemia virus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding protein/activating transcription factor pathway.

Authors:  Di Wang; Ming-Xiong Guo; Hai-Ming Hu; Zhou-Zhou Zhao; Hong-Ling Qiu; Huan-Jie Shao; Chen-Gang Zhu; Lu Xue; Yun-Bo Shi; Wen-Xin Li
Journal:  J Biol Chem       Date:  2008-03-28       Impact factor: 5.157

4.  A structural approach reveals how neighbouring C2H2 zinc fingers influence DNA binding specificity.

Authors:  Michael Garton; Hamed S Najafabadi; Frank W Schmitges; Ernest Radovani; Timothy R Hughes; Philip M Kim
Journal:  Nucleic Acids Res       Date:  2015-09-17       Impact factor: 16.971

5.  Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells.

Authors:  Li Hu; Wei Wang; Jinyang Cai; Jun Luo; Yi Huang; Shilu Xiong; Wenxin Li; Mingxiong Guo
Journal:  Oncol Lett       Date:  2013-04-24       Impact factor: 2.967

6.  Zinc fingers function cooperatively with KRAB domain for nuclear localization of KRAB-containing zinc finger proteins.

Authors:  Wei Wang; Jinyang Cai; Yi Lin; Zikou Liu; Qihao Ren; Li Hu; Zan Huang; Mingxiong Guo; Wenxin Li
Journal:  PLoS One       Date:  2014-03-19       Impact factor: 3.240

7.  KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly.

Authors:  Yi Liu; Wei Yin; Jingwen Wang; Yucong Lei; Guihong Sun; Wenxin Li; Zan Huang; Mingxiong Guo
Journal:  Cells       Date:  2019-12-10       Impact factor: 6.600

8.  Hsa_circRNA_000543 Predicts Poor Prognosis and Promotes Cervical Cancer Cell Progression Through Regulating miR-567/ZNF268 Axis.

Authors:  Zhilan Yao; Liuping Shu; Yi Yi; Lifu Qiao
Journal:  Cancer Manag Res       Date:  2021-06-30       Impact factor: 3.989
  8 in total

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