Literature DB >> 12822742

Novel actions of leptin in the hippocampus.

Jenni Harvey1.   

Abstract

It is well established that the obese gene product, leptin is an important circulating satiety factor that signals nutritional status to specific hypothalamic nuclei involved in body weight regulation. However, evidence is accumulating that, in addition to its pivotal role as an adiposity signal, leptin is a multi-faceted hormone that plays an important role in a plethora of CNS functions. In this review we summarize the recent advances made in leptin biology, with particular focus on its potential role as a cognitive enhancer and antiepileptic agent in the hippocampus.

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Year:  2003        PMID： 12822742     DOI： 10.1080/07853890310008251

Source DB:  PubMed          Journal:  Ann Med        ISSN： 0785-3890            Impact factor:   4.709


  14 in total

Review 1.  Cognitive and neuronal systems underlying obesity.

Authors:  Scott E Kanoski
Journal:  Physiol Behav       Date:  2012-01-12

2.  Leptin enhances NR2B-mediated N-methyl-D-aspartate responses via a mitogen-activated protein kinase-dependent process in cerebellar granule cells.

Authors:  A J Irving; L Wallace; D Durakoglugil; J Harvey
Journal:  Neuroscience       Date:  2006-01-18       Impact factor: 3.590

3.  Short-lived diabetes in the young-adult ZDF rat does not exacerbate neuronal Ca(2+) biomarkers of aging.

Authors:  Shaniya Maimaiti; Chris DeMoll; Katie L Anderson; Ryan B Griggs; Bradley K Taylor; Nada M Porter; Olivier Thibault
Journal:  Brain Res       Date:  2014-11-06       Impact factor: 3.252

Review 4.  Minireview: Food for thought: regulation of synaptic function by metabolic hormones.

Authors:  Gemma McGregor; Yasaman Malekizadeh; Jenni Harvey
Journal:  Mol Endocrinol       Date:  2015-01

Review 5.  'Adipaging': ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue.

Authors:  Laura M Pérez; Helios Pareja-Galeano; Fabián Sanchis-Gomar; Enzo Emanuele; Alejandro Lucia; Beatriz G Gálvez
Journal:  J Physiol       Date:  2016-05-10       Impact factor: 5.182

6.  Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study.

Authors:  Rachel A Whitmer; Erica P Gunderson; Elizabeth Barrett-Connor; Charles P Quesenberry; Kristine Yaffe
Journal:  BMJ       Date:  2005-04-29

7.  Downregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats.

Authors:  Claudia A Grillo; Gerardo G Piroli; Kris F Kaigler; Steven P Wilson; Marlene A Wilson; Lawrence P Reagan
Journal:  Behav Brain Res       Date:  2011-03-31       Impact factor: 3.332

8.  Leptin: a potential novel antidepressant.

Authors:  Xin-Yun Lu; Chung Sub Kim; Alan Frazer; Wei Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-19       Impact factor: 11.205

9.  Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli.

Authors:  Michael Rosenbaum; Melissa Sy; Katherine Pavlovich; Rudolph L Leibel; Joy Hirsch
Journal:  J Clin Invest       Date:  2008-07       Impact factor: 14.808

10.  Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents.

Authors:  Lin Xu; Nicholas Rensing; Xiao-Feng Yang; Hai Xia Zhang; Liu Lin Thio; Steven M Rothman; Aryan E Weisenfeld; Michael Wong; Kelvin A Yamada
Journal:  J Clin Invest       Date:  2008-01       Impact factor: 14.808
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