Literature DB >> 12821933

Role of nuclear and cytoplasmic localization in the tumour-suppressor activity of the von Hippel-Lindau protein.

Martin D Lewis1, Ben J Roberts.   

Abstract

Mutations in the von Hippel-Lindau (VHL) tumour-suppressor gene result in several forms of cancer. In the present study, we investigated the role of VHL subcellular localization in its antitumour properties. We generated renal cell carcinoma (RCC) lines stably expressing either exclusively nuclear (RCC/NLS-VHL), cytoplasmic (RCC/NES-VHL) or nucleo-cytoplasmic shuttling (RCC/DeltaNES-VHL or RCC/VHL) forms of VHL and investigated several parameters linked to tumorigenesis and known to be dysregulated in VHL disease. Remarkably, although the expression of wild-type VHL is largely cytoplasmic, all of the antitumour properties of VHL tested could be reconstituted by expressing exclusively nuclear VHL.

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Year:  2003        PMID： 12821933     DOI： 10.1038/sj.onc.1206683

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  12 in total

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Authors:  Mainak Guharoy; Pallab Bhowmick; Peter Tompa
Journal:  J Biol Chem       Date:  2016-02-05       Impact factor: 5.157

2.  pVHL-mediated transcriptional repression of c-Myc by recruitment of histone deacetylases.

Authors:  In-Young Hwang; Jae-Seok Roe; Ja-Hwan Seol; Hwa-Ryeon Kim; Eun-Jung Cho; Hong-Duk Youn
Journal:  Mol Cells       Date:  2012-02       Impact factor: 5.034

3.  Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility.

Authors:  Tien Hsu; Yair Adereth; Nurgun Kose; Vincent Dammai
Journal:  J Biol Chem       Date:  2006-02-27       Impact factor: 5.157

Review 4.  Von Hippel-Lindau syndrome: molecular mechanisms of the disease.

Authors:  María J Calzada
Journal:  Clin Transl Oncol       Date:  2010-03       Impact factor: 3.405

5.  The von Hippel-Lindau protein pVHL inhibits ribosome biogenesis and protein synthesis.

Authors:  Wen-Ting Zhao; Cheng-Fu Zhou; Xue-Bing Li; Yun-Fang Zhang; Li Fan; Jerry Pelletier; Jing Fang
Journal:  J Biol Chem       Date:  2013-04-23       Impact factor: 5.157

6.  An Elongin-Cullin-SOCS Box Complex Regulates Stress-Induced Serotonergic Neuromodulation.

Authors:  Xicotencatl Gracida; Michael F Dion; Gareth Harris; Yun Zhang; John A Calarco
Journal:  Cell Rep       Date:  2017-12-12       Impact factor: 9.423

Review 7.  Hypoxia-inducible factors and cancer.

Authors:  M J Calzada; L del Peso
Journal:  Clin Transl Oncol       Date:  2007-05       Impact factor: 3.405

8.  Lack of a functional VHL gene product sensitizes renal cell carcinoma cells to the apoptotic effects of the protein synthesis inhibitor verrucarin A.

Authors:  Girma M Woldemichael; Thomas J Turbyville; James R Vasselli; W Marston Linehan; James B McMahon
Journal:  Neoplasia       Date:  2012-08       Impact factor: 5.715

9.  Ubiquitin/SUMO modification regulates VHL protein stability and nucleocytoplasmic localization.

Authors:  Qiliang Cai; Erle S Robertson
Journal:  PLoS One       Date:  2010-09-09       Impact factor: 3.240

10.  Inadequate activation of the GTPase RhoA contributes to the lack of fibronectin matrix assembly in von Hippel-Lindau protein-defective renal cancer cells.

Authors:  Monica Feijóo-Cuaresma; Fernando Méndez; Alfredo Maqueda; Miguel A Esteban; Salvador Naranjo-Suarez; Maria C Castellanos; Mercedes Hernández del Cerro; Silvia N Vazquez; Angeles García-Pardo; Manuel O Landázuri; Maria J Calzada
Journal:  J Biol Chem       Date:  2008-06-19       Impact factor: 5.157
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