| Literature DB >> 12821804 |
Xi-Bin Liang1, Yong Luo, Xian-Yu Liu, Jun Lu, Feng-Qiao Li, Qian Wang, Xiao-Min Wang, Ji-Sheng Han.
Abstract
Low and high frequency electro-acupuncture (EA) stimulation was used in rats that had been lesioned by medial forebrain bundle transection. Behavioral tests showed that both low and high frequency EA stimulation significantly reduced the amphetamine-induced rotation 2 weeks after the lesion but only high frequency EA improved the rotational behavior at 4 weeks. Analysis of the dopamine content in the striatum did not show any significant change after EA. In situ hybridization showed that high frequency EA stimulation up-regulated the glial cell line-derived neurotrophic factor (GDNF) mRNA in both sides of the globus pallidus, while low frequency EA only affected the unlesioned side. It suggests that the retrograde nourishment of GDNF to the dopaminergic neurons and the balanced activity of different nuclei in the basal ganglia circuit after EA may contribute to the behavioral improvement in these rats, which might be the factors that underlie the effectiveness of EA in the treatment of Parkinson's disease.Entities:
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Year: 2003 PMID： 12821804 DOI： 10.1097/00001756-200306110-00015
Source DB: PubMed Journal: Neuroreport ISSN： 0959-4965 Impact factor: 1.837