Literature DB >> 128217

Strand breakage in rat brain DNA and its repair induced by ethylnitrosourea in vivo.

D Hadjiolov, L Venkov.   

Abstract

The damage and repair of rat brain DNA was studied in vivo after a single carcinogenic dose of ethylnitrosourea. Fragmentation of the brain DNA produced by this carcinogen was demonstrated on alkaline sucrose gradients. By the 24th hrs after treatment with ethylnitrosourea the single-strand damage to DNA was not completely repaired. As the highly differentiated cells of the central nervous system do not proliferate, it is possible that during brain carcinogenesis delayed repair of DNA of primitive cells might be needed for the formation of tumor anlage.

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Year:  1975        PMID： 128217     DOI： 10.1007/bf00312244

Source DB:  PubMed          Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol        ISSN： 0084-5353


  6 in total

1.  Patterns of damage and repair of liver DNA induced by carcinogenic methylating agents in vivo.

Authors:  I Damjanov; R Cox; D S Sarma; E Farber
Journal:  Cancer Res       Date:  1973-09       Impact factor: 12.701

2.  A method for measuring DNA damage and repair in the liver in vivo.

Authors:  R Cox; I Damjanov; S E Abanobi; D S Sarma
Journal:  Cancer Res       Date:  1973-09       Impact factor: 12.701

3.  [Induction of neurogenic malignancies by one single dose of ethyl-nitrosourea (ENU) given to newborn and juvenile BD IX-strain rats].

Authors:  H Druckrey; B Schagen; S Ivankovic
Journal:  Z Krebsforsch       Date:  1970

4.  Thymic lymphoma and myeloid leukemia in the rat induced with ethylnitrosourea.

Authors:  D Hadjiolov
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1972

5.  Molecular and cellular mechanisms associated with pulse-carcinogenesis in the rat nerbous system by ethyinitrosourea: ethylation of nucleic acids and elimination rates of ethylated bases from the DNA of different tissues.

Authors:  R Goth; M F Rajewsky
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1974

6.  Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea.

Authors:  R Goth; M F Rajewsky
Journal:  Proc Natl Acad Sci U S A       Date:  1974-03       Impact factor: 11.205
  6 in total

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