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Literature DB >> 12821503

Addition of caspofungin to fluconazole does not improve outcome in murine candidiasis.

John R Graybill¹, Rosie Bocanegra, Laura K Najvar, Steve Hernandez, Robert A Larsen.

Abstract

Caspofungin is a potent antifungal inhibiting glucan synthesis in Candida species. However, caspofungin is not 100% curative in candidiasis. Therefore, we evaluated combinations of fluconazole with caspofungin for murine candidemia. We could not show any benefit of combined therapy over individual antifungal drugs.

Entities: Chemical Disease Species

Mesh：

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Year: 2003 PMID： 12821503 PMCID： PMC161841 DOI： 10.1128/AAC.47.7.2373-2375.2003

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

6 in total

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Authors: Jorge Mora-Duarte; Robert Betts; Coleman Rotstein; Arnaldo Lopes Colombo; Luis Thompson-Moya; Juanita Smietana; Robert Lupinacci; Carole Sable; Nicholas Kartsonis; John Perfect
Journal: N Engl J Med Date: 2002-12-19 Impact factor: 91.245

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Journal: N Engl J Med Date: 1994-11-17 Impact factor: 91.245

6 in total

14 in total

Review 1. Combination antifungal therapy.

Authors: Melissa D Johnson; Conan MacDougall; Luis Ostrosky-Zeichner; John R Perfect; John H Rex
Journal: Antimicrob Agents Chemother Date: 2004-03 Impact factor: 5.191

2. Need for early antifungal treatment confirmed in experimental disseminated Candida albicans infection.

Authors: Donna M MacCallum; Frank C Odds
Journal: Antimicrob Agents Chemother Date: 2004-12 Impact factor: 5.191

Review 3. Combination treatment of invasive fungal infections.

Authors: Pranab K Mukherjee; Daniel J Sheehan; Christopher A Hitchcock; Mahmoud A Ghannoum
Journal: Clin Microbiol Rev Date: 2005-01 Impact factor: 26.132

4. Mechanism underlying renal failure caused by pathogenic Candida albicans infection.

Authors: Shin Jae-Chen; Jeon Young-Joo; Park Seon-Min; Seo Kang Seok; Shim Jung-Hyun; Chae Jung-Il
Journal: Biomed Rep Date: 2014-11-24

5. Caspofungin inhibits Rhizopus oryzae 1,3-beta-D-glucan synthase, lowers burden in brain measured by quantitative PCR, and improves survival at a low but not a high dose during murine disseminated zygomycosis.

Authors: Ashraf S Ibrahim; Joel C Bowman; Valentina Avanessian; Keturah Brown; Brad Spellberg; John E Edwards; Cameron M Douglas
Journal: Antimicrob Agents Chemother Date: 2005-02 Impact factor: 5.191