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Literature DB >> 12821483

Intracellular release of nitric oxide by NCX 972, an NO-releasing metronidazole, enhances in vitro killing of Entamoeba histolytica.

Anna Sannella¹, Luigi Gradoni, Tiziana Persichini, Ennio Ongini, Giorgio Venturini, Marco Colasanti.

Abstract

The activity of NCX 972, a new molecule obtained by adding a nitric oxide (NO) moiety to metronidazole, was tested against six isolates of Entamoeba histolytica in xenic cultures. NCX 972 released NO into trophozoite cells and enhanced killing of amoebas in a dose- and time-dependent manner compared to metronidazole.

Entities: Chemical Species

Mesh：

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Year: 2003 PMID： 12821483 PMCID： PMC161880 DOI： 10.1128/AAC.47.7.2303-2306.2003

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

23 in total

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6. Innate immunity to amebic liver abscess is dependent on gamma interferon and nitric oxide in a murine model of disease.

Authors: K B Seydel; S J Smith; S L Stanley
Journal: Infect Immun Date: 2000-01 Impact factor: 3.441

Intracellular release of nitric oxide by NCX 972, an NO-releasing metronidazole, enhances in vitro killing of Entamoeba histolytica.

Review 1. Nitric oxide and parasitic disease.

2. Entamoeba taxonomy.

3. Temporal and anatomical distribution of nitric oxide synthase mRNA expression and nitric oxide production during central nervous system inflammation.

4. Metronidazole resistance in the protozoan parasite Entamoeba histolytica is associated with increased expression of iron-containing superoxide dismutase and peroxiredoxin and decreased expression of ferredoxin 1 and flavin reductase.

Review 5. Cysteine proteinases and the pathogenesis of amebiasis.

6. Innate immunity to amebic liver abscess is dependent on gamma interferon and nitric oxide in a murine model of disease.

Review 7. NO inhibitions: antimicrobial properties of nitric oxide.

Review 8. Metronidazole. A therapeutic review and update.

9. Specific labeling of cysteine proteinases in pathogenic and nonpathogenic Entamoeba histolytica.

10. Macrophage cytotoxicity against Entamoeba histolytica trophozoites is mediated by nitric oxide from L-arginine.

Review 1. Nitroaromatic Antibiotics as Nitrogen Oxide Sources.