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Literature DB >> 1282071

Modulation of the induction of nitric oxide synthase by eicosanoids in the murine macrophage cell line J774.

Abstract

The effect of eicosanoids on the induction of nitric oxide synthase in the murine macrophage cell line J774 has been studied. We found that prostaglandin E2 (PGE2) and iloprost (a stable analogue of prostacyclin) both at nanomolar concentrations inhibited the lipopolysaccharide stimulated induction of NO synthase. In contrast PGF2 alpha, U46619, a stable analogue of thromboxane A2, leukotrienes B4 and C4 had no effect. These data demonstrate that the L-arginine: NO pathway in macrophages may be modulated by prostanoids.

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Year: 1992 PMID： 1282071 PMCID： PMC1907741 DOI： 10.1111/j.1476-5381.1992.tb14499.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

8 in total

1. Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages.

Authors: M Di Rosa; M Radomski; R Carnuccio; S Moncada
Journal: Biochem Biophys Res Commun Date: 1990-11-15 Impact factor: 3.575

2. Nitric oxide: a cytotoxic activated macrophage effector molecule.

Authors: J B Hibbs; R R Taintor; Z Vavrin; E M Rachlin
Journal: Biochem Biophys Res Commun Date: 1988-11-30 Impact factor: 3.575

3. Interdependence of tumor necrosis factor, prostaglandin E2, and protein synthesis in lipopolysaccharide-exposed rat Kupffer cells.

Authors: T Peters; U Karck; K Decker
Journal: Eur J Biochem Date: 1990-08-17

4. Release of tumor necrosis factor-alpha from macrophages. Enhancement and suppression are dose-dependently regulated by prostaglandin E2 and cyclic nucleotides.

Authors: H Renz; J H Gong; A Schmidt; M Nain; D Gemsa
Journal: J Immunol Date: 1988-10-01 Impact factor: 5.422

5. Macrophage-mediated tumor cell killing: regulation of expression of cytolytic activity by prostaglandin E.

Authors: S M Taffet; S W Russell
Journal: J Immunol Date: 1981-02 Impact factor: 5.422

6. Evidence for two sources of arachidonic acid for oxidative metabolism by mouse peritoneal macrophages.

Authors: J L Humes; S Sadowski; M Galavage; M Goldenberg; E Subers; R J Bonney; F A Kuehl
Journal: J Biol Chem Date: 1982-02-25 Impact factor: 5.157

7. Interferon-gamma and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages.

Authors: J C Drapier; J Wietzerbin; J B Hibbs
Journal: Eur J Immunol Date: 1988-10 Impact factor: 5.532

8. Effects of various inhibitors of arachidonic acid oxygenation on macrophage superoxide release and tumoricidal activity.

Authors: R M Schultz; S K Nanda; M G Altom
Journal: J Immunol Date: 1985-09 Impact factor: 5.422

8 in total

32 in total

1. Salmonella pathogenicity island 2-dependent expression of suppressor of cytokine signaling 3 in macrophages.

Authors: Kei-Ichi Uchiya; Toshiaki Nikai
Journal: Infect Immun Date: 2005-09 Impact factor: 3.441

2. Phosphodiesterase 2A is a major negative regulator of iNOS expression in lipopolysaccharide-treated mouse alveolar macrophages.

Authors: Otgonchimeg Rentsendorj; Franco R D'Alessio; David B Pearse
Journal: J Leukoc Biol Date: 2014-07-25 Impact factor: 4.962

9. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide.

Authors: C J Lowenstein; E W Alley; P Raval; A M Snowman; S H Snyder; S W Russell; W J Murphy
Journal: Proc Natl Acad Sci U S A Date: 1993-10-15 Impact factor: 11.205

10. Eicosanoid-dependence of responses of pre- but not postglomerular vessels to noradrenaline in rat isolated kidneys.

Authors: B L Zhang; J Sassard
Journal: Br J Pharmacol Date: 1993-09 Impact factor: 8.739

Modulation of the induction of nitric oxide synthase by eicosanoids in the murine macrophage cell line J774.

1. Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages.

2. Nitric oxide: a cytotoxic activated macrophage effector molecule.

3. Interdependence of tumor necrosis factor, prostaglandin E2, and protein synthesis in lipopolysaccharide-exposed rat Kupffer cells.

4. Release of tumor necrosis factor-alpha from macrophages. Enhancement and suppression are dose-dependently regulated by prostaglandin E2 and cyclic nucleotides.

5. Macrophage-mediated tumor cell killing: regulation of expression of cytolytic activity by prostaglandin E.

6. Evidence for two sources of arachidonic acid for oxidative metabolism by mouse peritoneal macrophages.

7. Interferon-gamma and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages.

8. Effects of various inhibitors of arachidonic acid oxygenation on macrophage superoxide release and tumoricidal activity.

1. Salmonella pathogenicity island 2-dependent expression of suppressor of cytokine signaling 3 in macrophages.

2. Phosphodiesterase 2A is a major negative regulator of iNOS expression in lipopolysaccharide-treated mouse alveolar macrophages.

Review 3. Chronic nitric oxide inhibition model six years on.

4. Protection of islet cells from inflammatory cell death in vitro.

5. Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoids.

6. Role of nitric oxide and cyclooxygenase pathway in lipopolysaccharide-induced intussusception.

7. Modulation by nitric oxide and prostaglandin of the renal vascular response to angiotensin II (3-8).

8. Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock.

9. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide.

10. Eicosanoid-dependence of responses of pre- but not postglomerular vessels to noradrenaline in rat isolated kidneys.