BACKGROUND: Several studies suggest that immunological components play a key role in the development of cervical cancer. Polymorphism in the IL-1 RA gene was associated with various malignant diseases. Data is lacking for cervical cancer. MATERIALS AND METHODS: In a prospective study we analysed the polymorphism of IL-1RA in 113 women with cervical cancer and 107 with benign diseases. Genomic DNA fragments were amplified by PCR. RESULTS: The distribution of genotype frequencies was different between the study and control group with respect to allele 2 heterozygotes (24.8% vs. 13.1%; p = 0.04) but not in the frequencies of allele 1/3 and homozygous allele 2. There were no differences between IL-1 RA 1/2 polymorphism and all other alleles in tumour stage, grading, recurrence status and age. CONCLUSION: This data supports the role for allele 2 of the gene encoding for IL1-RA as a genetic determinant of cervical cancer.
BACKGROUND: Several studies suggest that immunological components play a key role in the development of cervical cancer. Polymorphism in the IL-1 RA gene was associated with various malignant diseases. Data is lacking for cervical cancer. MATERIALS AND METHODS: In a prospective study we analysed the polymorphism of IL-1RA in 113 women with cervical cancer and 107 with benign diseases. Genomic DNA fragments were amplified by PCR. RESULTS: The distribution of genotype frequencies was different between the study and control group with respect to allele 2 heterozygotes (24.8% vs. 13.1%; p = 0.04) but not in the frequencies of allele 1/3 and homozygous allele 2. There were no differences between IL-1 RA 1/2 polymorphism and all other alleles in tumour stage, grading, recurrence status and age. CONCLUSION: This data supports the role for allele 2 of the gene encoding for IL1-RA as a genetic determinant of cervical cancer.
Authors: Zhu Zhang; Bin Zhou; Qianqian Gao; Yuke Wu; Kui Zhang; Yan Pu; Yaping Song; Lin Zhang; Mingrong Xi Journal: Fam Cancer Date: 2014-12 Impact factor: 2.375
Authors: Hugo Sousa; Alexandra M Santos; Raquel Catarino; Daniela Pinto; José Moutinho; Paulo Canedo; José Carlos Machado; Rui Medeiros Journal: Mol Biol Rep Date: 2012-10-10 Impact factor: 2.316
Authors: Yang Zhang; Erich M Sturgis; Yan Sun; Chuanzheng Sun; Qingyi Wei; Zhigang Huang; Guojun Li Journal: Eur J Cancer Date: 2015-05-14 Impact factor: 9.162
Authors: S P Balasubramanian; I A F Azmy; S E Higham; A G Wilson; S S Cross; A Cox; N J Brown; M W Reed Journal: BMC Cancer Date: 2006-07-14 Impact factor: 4.430