Literature DB >> 12820239

Antiplasmodial activity of extracts and quassinoids isolated from seedlings of Ailanthus altissima (Simaroubaceae).

Adewole L Okunade1, Rachel E Bikoff, Steven J Casper, Anna Oksman, Daniel E Goldberg, Walter H Lewis.   

Abstract

Extracts and isolated compounds from seedlings of Ailanthus altissima, were assessed for antiplasmodial activity in vitro. Two quassinoids, ailanthone and 6alpha-tigloyloxychaparrinone, isolated from the active extracts showed activity against both chloroquine-resistant and chloroquine-sensitive strains of Plasmodium falciparum in vitro. Only ailanthone demonstrated low toxicity against the Vero cell line (kidney cells from the African green monkey). This is the first report of the isolation and antiplasmodial activity of 6alpha-tigloyloxychaparrinone from this species. Copyright 2003 John Wiley & Sons, Ltd.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12820239     DOI： 10.1002/ptr.1336

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  11 in total

Review 1.  Review on Invasive Tree of Heaven (Ailanthus altissima (Mill.) Swingle) Conflicting Values: Assessment of Its Ecosystem Services and Potential Biological Threat.

Authors:  Barbara Sladonja; Marta Sušek; Julia Guillermic
Journal:  Environ Manage       Date:  2015-06-14       Impact factor: 3.266

2.  Antitumor activity of the Ailanthus altissima bark phytochemical ailanthone against breast cancer MCF-7 cells.

Authors:  Ruxing Wang; Yanjie Lu; Hong Li; Lixin Sun; Ning Yang; Mingzhen Zhao; Manli Zhang; Qingwen Shi
Journal:  Oncol Lett       Date:  2018-02-13       Impact factor: 2.967

Review 3.  Ailanthone: A novel potential drug for treating human cancer.

Authors:  Haixiang Ding; Xiuchong Yu; Chen Hang; Kaijun Gao; Xifeng Lao; Yangtao Jia; Zhilong Yan
Journal:  Oncol Lett       Date:  2020-06-09       Impact factor: 2.967

4.  Ailanthone induces autophagic and apoptotic cell death in human promyelocytic leukemia HL-60 cells.

Authors:  Cheng Wei; Chuanrong Chen; Yuxin Cheng; Lin Zhu; Yu Wang; Can Luo; Yang He; Zhiming Yang; Zhaoning Ji
Journal:  Oncol Lett       Date:  2018-07-06       Impact factor: 2.967

5.  Ailanthone Induces Cell Cycle Arrest and Apoptosis in Melanoma B16 and A375 Cells.

Authors:  Wenjing Liu; Xiaona Liu; Zhaohai Pan; Dan Wang; Minjing Li; Xiaoyu Chen; Ling Zhou; Maolei Xu; Defang Li; Qiusheng Zheng
Journal:  Biomolecules       Date:  2019-07-11

6.  Ailanthone Inhibits Huh7 Cancer Cell Growth via Cell Cycle Arrest and Apoptosis In Vitro and In Vivo.

Authors:  Zhenjian Zhuo; Jianyang Hu; Xiaolin Yang; Minfen Chen; Xueping Lei; Lijuan Deng; Nan Yao; Qunlong Peng; Zhesheng Chen; Wencai Ye; Dongmei Zhang
Journal:  Sci Rep       Date:  2015-11-03       Impact factor: 4.379

7.  Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer.

Authors:  Yundong He; Shihong Peng; Jinhua Wang; Huang Chen; Xiaonan Cong; Ang Chen; Meichun Hu; Min Qin; Haigang Wu; Shuman Gao; Liguo Wang; Xin Wang; Zhengfang Yi; Mingyao Liu
Journal:  Nat Commun       Date:  2016-12-13       Impact factor: 14.919

8.  Anti-plasmodial effect of plant extracts from Picrolemma huberi and Picramnia latifolia.

Authors:  Wendy Berthi; Alexa González; Alexandra Rios; Silvia Blair; Álvaro Cogollo; Adriana Pabón
Journal:  Malar J       Date:  2018-04-04       Impact factor: 2.979

9.  Ailanthone induces G2/M cell cycle arrest and apoptosis of SGC‑7901 human gastric cancer cells.

Authors:  Yuxin Chen; Ling Zhu; Xi Yang; Cheng Wei; Chuanrong Chen; Yang He; Zhaoning Ji
Journal:  Mol Med Rep       Date:  2017-09-13       Impact factor: 2.952

10.  Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.

Authors:  Chun-Ming Wang; Hua-Fu Li; Xiao-Kun Wang; Wu-Guo Li; Qiao Su; Xing Xiao; Teng-Fei Hao; Wei Chen; Ya-Wei Zhang; Hai-Yong Zhang; Wang Wu; Zhen-Ran Hu; Guang-Yin Zhao; Ming-Yu Huo; Yu-Long He; Chang-Hua Zhang
Journal:  Int J Biol Sci       Date:  2021-07-05       Impact factor: 6.580
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.