Yukihisa Suzuki1,2, Motohiro Kiyosawa3,4, Naonori Ohno1, Manabu Mochizuki1, Akira Inaba5, Hidehiro Mizusawa6, Kenji Ishii2, Michio Senda2. 1. Department of Ophthalmology and Visual Science, School of Medicine, Tokyo Medical and Dental University, Yushima 1-chome 5-45, Bunkyo-ku, 113-8519 , Tokyo, Japan. 2. Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan. 3. Department of Ophthalmology and Visual Science, School of Medicine, Tokyo Medical and Dental University, Yushima 1-chome 5-45, Bunkyo-ku, 113-8519 , Tokyo, Japan. m.kiyosawa.oph@tmd.ac.jp. 4. Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan. m.kiyosawa.oph@tmd.ac.jp. 5. Laboratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan. 6. Department of Neurology, Tokyo Medical and Dental University, Tokyo, Japan.
Abstract
PURPOSE: To determine whether regional cerebral functional abnormalities exist in patients with apraxia of lid opening (ALO). METHODS: Cerebral glucose metabolism was examined by positron emission tomography (PET) in 11 patients (8 women and 3 men, age 48-69 years); 10 with ALO accompanied by blepharospasm and 1 patient with pure ALO. Eleven normal volunteers (6 women and 5 men, age 45-66 years) were examined as controls. A comprehensive ophthalmological examination, magnetic resonance imaging (MRI), and PET were performed. The cerebral glucose metabolism was evaluated by the relative uptake of [fluorine-18]fluorodeoxyglucose by PET. The mean +/- two standard deviations of the normal controls was defined as the normal range for cerebral glucose metabolism. RESULTS: MRI revealed no particular lesion except for an infarction in the unilateral basal ganglia in two patients. Decreased glucose metabolism was observed in a wide area of the medial frontal lobe (six cases) and primary visual cortex (PVC) (four cases). Group multiple comparisons revealed a significant decrease ( P<0.0035) in the bilateral anterior cingulate gyrus, left supplementary motor area (SMA), and bilateral PVC. CONCLUSION: The results support the hypothesis that ALO is associated with hypofunction in the SMA and/or anterior cingulate gyrus.
PURPOSE: To determine whether regional cerebral functional abnormalities exist in patients with apraxia of lid opening (ALO). METHODS:Cerebral glucose metabolism was examined by positron emission tomography (PET) in 11 patients (8 women and 3 men, age 48-69 years); 10 with ALO accompanied by blepharospasm and 1 patient with pure ALO. Eleven normal volunteers (6 women and 5 men, age 45-66 years) were examined as controls. A comprehensive ophthalmological examination, magnetic resonance imaging (MRI), and PET were performed. The cerebral glucose metabolism was evaluated by the relative uptake of [fluorine-18]fluorodeoxyglucose by PET. The mean +/- two standard deviations of the normal controls was defined as the normal range for cerebral glucose metabolism. RESULTS: MRI revealed no particular lesion except for an infarction in the unilateral basal ganglia in two patients. Decreased glucose metabolism was observed in a wide area of the medial frontal lobe (six cases) and primary visual cortex (PVC) (four cases). Group multiple comparisons revealed a significant decrease ( P<0.0035) in the bilateral anterior cingulate gyrus, left supplementary motor area (SMA), and bilateral PVC. CONCLUSION: The results support the hypothesis that ALO is associated with hypofunction in the SMA and/or anterior cingulate gyrus.
Authors: G Galardi; D Perani; F Grassi; S Bressi; S Amadio; M Antoni; G C Comi; N Canal; F Fazio Journal: Acta Neurol Scand Date: 1996-09 Impact factor: 3.209
Authors: M Aramideh; B W Ongerboer de Visser; J H Koelman; L J Bour; P P Devriese; J D Speelman Journal: Mov Disord Date: 1994-07 Impact factor: 10.338