Literature DB >> 12819904

Quantitative traits associated with the Type 2 diabetes susceptibility allele in Kir6.2.

M N Weedon, A L Gloyn, T M Frayling, A T Hattersley, G Davey Smith, Y Ben-Shlomo.   

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Year:  2003        PMID： 12819904     DOI： 10.1007/s00125-003-1135-3

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


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  9 in total

1.  K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels.

Authors:  Christina Schwanstecher; Ulrike Meyer; Mathias Schwanstecher
Journal:  Diabetes       Date:  2002-03       Impact factor: 9.461

2.  A putative functional polymorphism in the IGF-I gene: association studies with type 2 diabetes, adult height, glucose tolerance, and fetal growth in U.K. populations.

Authors:  Timothy M Frayling; Andrew T Hattersley; Anne McCarthy; Jeff Holly; Simon M S Mitchell; Anna L Gloyn; Katharine Owen; David Davies; George Davey Smith; Yoav Ben-Shlomo
Journal:  Diabetes       Date:  2002-07       Impact factor: 9.461

3.  E23K single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of Type II diabetes in Caucasians as the PPARgamma Pro12Ala variant.

Authors:  L Love-Gregory; J Wasson; J Lin; G Skolnick; B Suarez; M A Permutt
Journal:  Diabetologia       Date:  2003-01       Impact factor: 10.122

Review 4.  Of mice and men: K(ATP) channels and insulin secretion.

Authors:  L Aguilar-Bryan; J Bryan; M Nakazaki
Journal:  Recent Prog Horm Res       Date:  2001

5.  Morphological changes in pancreatic islets of KATP channel-deficient mice: the involvement of KATP channels in the survival of insulin cells and the maintenance of islet architecture.

Authors:  A Winarto; T Miki; S Seino; T Iwanaga
Journal:  Arch Histol Cytol       Date:  2001-02

6.  The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes.

Authors:  Eva-Maria D Nielsen; Lars Hansen; Bendix Carstensen; Søren M Echwald; Thomas Drivsholm; Charlotte Glümer; Birger Thorsteinsson; Knut Borch-Johnsen; Torben Hansen; Oluf Pedersen
Journal:  Diabetes       Date:  2003-02       Impact factor: 9.461

7.  Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.

Authors:  Anna L Gloyn; Michael N Weedon; Katharine R Owen; Martina J Turner; Bridget A Knight; Graham Hitman; Mark Walker; Jonathan C Levy; Mike Sampson; Stephanie Halford; Mark I McCarthy; Andrew T Hattersley; Timothy M Frayling
Journal:  Diabetes       Date:  2003-02       Impact factor: 9.461

8.  Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K(+) channel in the beta-cell.

Authors:  Leen M 't Hart; Timon W van Haeften; Jacqueline M Dekker; Martine Bot; Robert J Heine; J Antonie Maassen
Journal:  Diabetes       Date:  2002-10       Impact factor: 9.461

9.  The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia.

Authors:  Otto Tschritter; Michael Stumvoll; Fausto Machicao; Martin Holzwarth; Melanie Weisser; Elke Maerker; Anna Teigeler; Hans Häring; Andreas Fritsche
Journal:  Diabetes       Date:  2002-09       Impact factor: 9.461
  9 in total
  5 in total

1.  No evidence that established type 2 diabetes susceptibility variants in the PPARG and KCNJ11 genes have pleiotropic effects on early growth.

Authors:  A J Bennett; U Sovio; A Ruokonen; H Martikainen; A Pouta; A-L Hartikainen; S Franks; P Elliott; M-R Järvelin; M I McCarthy
Journal:  Diabetologia       Date:  2007-11-10       Impact factor: 10.122

2.  No association between insulin gene variation and adult metabolic phenotypes in a large Finnish birth cohort.

Authors:  A Bennett; U Sovio; A Ruokonen; H Martikainen; A Pouta; S Taponen; A-L Hartikainen; S Franks; L Peltonen; P Elliott; M-R Järvelin; M I McCarthy
Journal:  Diabetologia       Date:  2005-04-16       Impact factor: 10.122

3.  Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.

Authors:  Angharad R Morgan; John M D Thompson; Rinki Murphy; Peter N Black; Wen-Jiun Lam; Lynnette R Ferguson; Ed A Mitchell
Journal:  BMC Med Genet       Date:  2010-08-16       Impact factor: 2.103

4.  Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans.

Authors:  Nicholette D Palmer; Carl D Langefeld; Michael Bryer-Ash; Jerome I Rotter; Kent D Taylor; Donald W Bowden
Journal:  J Clin Endocrinol Metab       Date:  2008-09-16       Impact factor: 5.958

5.  Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.

Authors:  Rachel M Freathy; Michael N Weedon; Amanda Bennett; Elina Hypponen; Caroline L Relton; Beatrice Knight; Beverley Shields; Kirstie S Parnell; Christopher J Groves; Susan M Ring; Marcus E Pembrey; Yoav Ben-Shlomo; David P Strachan; Chris Power; Marjo-Riitta Jarvelin; Mark I McCarthy; George Davey Smith; Andrew T Hattersley; Timothy M Frayling
Journal:  Am J Hum Genet       Date:  2007-04-23       Impact factor: 11.025
  5 in total

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