Literature DB >> 12819118

Deletion of a Vibrio cholerae ClC channel results in acid sensitivity and enhanced intestinal colonization.

Yanpeng Ding1, Matthew K Waldor.   

Abstract

ClC chloride channels are found in all three kingdoms of life though little is known about their functions in prokaryotes. Here we investigated the role of a Vibrio cholerae ClC channel in acid resistance and intestinal colonization. The putative V. cholerae ClC channel was found to confer mild resistance to acid when pH was adjusted with HCl, but not with other acids. Surprisingly, a ClC channel deletion mutant exhibited enhanced intestinal colonization in infant mice.

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Year:  2003        PMID： 12819118      PMCID： PMC161967          DOI： 10.1128/IAI.71.7.4197-4200.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  20 in total

1.  X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity.

Authors:  Raimund Dutzler; Ernest B Campbell; Martine Cadene; Brian T Chait; Roderick MacKinnon
Journal:  Nature       Date:  2002-01-17       Impact factor: 49.962

2.  Chloride channels are different.

Authors:  Thomas J Jentsch
Journal:  Nature       Date:  2002-01-17       Impact factor: 49.962

Review 3.  From stones to bones: the biology of ClC chloride channels.

Authors:  A L George; L Bianchi; E M Link; C G Vanoye
Journal:  Curr Biol       Date:  2001-08-07       Impact factor: 10.834

4.  Selection for in vivo regulators of bacterial virulence.

Authors:  S H Lee; S M Butler; A Camilli
Journal:  Proc Natl Acad Sci U S A       Date:  2001-06-05       Impact factor: 11.205

5.  A biological role for prokaryotic ClC chloride channels.

Authors:  Ramkumar Iyer; Tina M Iverson; Alessio Accardi; Christopher Miller
Journal:  Nature       Date:  2002-10-17       Impact factor: 49.962

6.  High-level expression, functional reconstitution, and quaternary structure of a prokaryotic ClC-type chloride channel.

Authors:  M Maduke; D J Pheasant; C Miller
Journal:  J Gen Physiol       Date:  1999-11       Impact factor: 4.086

7.  CTXphi contains a hybrid genome derived from tandemly integrated elements.

Authors:  B M Davis; M K Waldor
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-18       Impact factor: 11.205

8.  Vibrio cholerae intestinal population dynamics in the suckling mouse model of infection.

Authors:  M J Angelichio; J Spector; M K Waldor; A Camilli
Journal:  Infect Immun       Date:  1999-08       Impact factor: 3.441

9.  Open-state substructure of single chloride channels from Torpedo electroplax.

Authors:  C Miller
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1982-12-01       Impact factor: 6.237

Review 10.  ClC chloride channels.

Authors:  J A Mindell; M Maduke
Journal:  Genome Biol       Date:  2001-02-07       Impact factor: 13.583
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  6 in total

Review 1.  Abundant Monovalent Ions as Environmental Signposts for Pathogens during Host Colonization.

Authors:  Shumin Tan
Journal:  Infect Immun       Date:  2021-03-17       Impact factor: 3.441

2.  The crystal structure of AphB, a virulence gene activator from Vibrio cholerae, reveals residues that influence its response to oxygen and pH.

Authors:  Jennifer L Taylor; Rukman S De Silva; Gabriela Kovacikova; Wei Lin; Ronald K Taylor; Karen Skorupski; F Jon Kull
Journal:  Mol Microbiol       Date:  2012-01-10       Impact factor: 3.501

3.  The LysR-type regulator LeuO regulates the acid tolerance response in Vibrio cholerae.

Authors:  Vanessa M Ante; X Renee Bina; James E Bina
Journal:  Microbiology       Date:  2015-09-29       Impact factor: 2.777

4.  The LysR-type virulence activator AphB regulates the expression of genes in Vibrio cholerae in response to low pH and anaerobiosis.

Authors:  Gabriela Kovacikova; Wei Lin; Karen Skorupski
Journal:  J Bacteriol       Date:  2010-06-18       Impact factor: 3.490

Review 5.  Efficient responses to host and bacterial signals during Vibrio cholerae colonization.

Authors:  Francesca P Rothenbacher; Jun Zhu
Journal:  Gut Microbes       Date:  2013-10-31

6.  In vivo repressed genes of Vibrio cholerae reveal inverse requirements of an H+/Cl- transporter along the gastrointestinal passage.

Authors:  Fatih Cakar; Franz G Zingl; Manuel Moisi; Joachim Reidl; Stefan Schild
Journal:  Proc Natl Acad Sci U S A       Date:  2018-02-20       Impact factor: 11.205
  6 in total

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