Literature DB >> 1281891

Interleukin-2 inhibits the GABA-induced Cl- current in identified Aplysia neurons.

M Sawada1, N Hara, M Ichinose.   

Abstract

The effects of extracellularly applied recombinant human interleukin-2 (rhIL-2) on the gamma-aminobutyric acid (GABA)-induced Cl- current recorded from identified neurons (R9 and R12) of Aplysia kurodai were investigated with conventional voltage-clamp and pressure ejection techniques. Bath-applied rhIL-2 (10-40 U/ml) reduced the GABA-induced current in the neurons without affecting resting membrane conductance and the holding current. The suppressing effect of rhIL-2 on the current was completely reversible. Heat-inactivated rhIL-2 was without effect. These results suggest that the immunomodulator IL-2 can modulate the GABA-induced response in the nervous system.

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Year:  1992        PMID： 1281891     DOI： 10.1002/jnr.490330312

Source DB:  PubMed          Journal:  J Neurosci Res        ISSN： 0360-4012            Impact factor:   4.164


  3 in total

1.  Thalamocortical bistable switch as a theoretical model of fibromyalgia pathogenesis inferred from a literature survey.

Authors:  Ilaria Demori; Giulia Giordano; Viviana Mucci; Serena Losacco; Lucio Marinelli; Paolo Massobrio; Franco Blanchini; Bruno Burlando
Journal:  J Comput Neurosci       Date:  2022-07-11       Impact factor: 1.453

2.  Inhibition of the calcitonin-induced outward current in identified Aplysia neurons by interleukin-1 and interleukin-2.

Authors:  M Sawada; M Ichinose; G B Stefano
Journal:  Cell Mol Neurobiol       Date:  1994-04       Impact factor: 5.046

3.  Comparative analysis of the expression of c-Fos and interleukin-2 proteins in hypothalamus cells during various treatments.

Authors:  S V Barabanova; Z E Artyukhina; K T Ovchinnikova; T V Abramova; T B Kazakova; V Kh Khavinson; V V Malinin; E A Korneva
Journal:  Neurosci Behav Physiol       Date:  2008-03
  3 in total

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