Determination of pantoprazole by adsorptive stripping voltammetry at carbon paste electrode.

A voltammetric method was described for the determination of pantoprazole by differential-pulse adsorptive stripping voltammetry at a carbon paste electrode. Accumulation of pantoprazole was found to be optimized in Britton-Robinson buffer (0.04 M, pH 4.0) solution following 5 min accumulation time at open circuit condition. Under optimized conditions, the current showed a linear dependence with concentration in the range 1.0 x 10(-7)-1.0 x 10(-5) M. The detection limit was 2.0 x 10(-8) M. The method was applied successfully for the analysis of pantoprazole in tablet dosage form. The results of accuracy and precision were comparable to those obtained by spectrophotometry.