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Literature DB >> 1281849

Effects of aprotinin on hemorrhagic complications in ARDS patients during prolonged extracorporeal CO2 removal.

F Brunet¹, J P Mira, M Belghith, J J Lanore, S Schlumberger, P Toulon, J F Dhainaut.

Abstract

The effects of aprotinin, a broad-based proteinase inhibitor, in the management of hemorrhagic complications during prolonged venovenous extracorporeal CO2 removal in patients with adult respiratory distress syndrome are not evaluated. In two patients, aprotinin infusion was added to heparin to treat bleeding, occurring after few days of bypass and responsible for respiratory and hemodynamic deterioration. After aprotinin infusion (loading dose of 2 x 10(6) kIU followed by a continuous infusion of 5 x 10(5) kIU/h) combined with heparin, bleeding vanished until the end of bypass.

Entities: Chemical Disease Species

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Year: 1992 PMID： 1281849 DOI： 10.1007/BF01694366

Source DB: PubMed Journal: Intensive Care Med ISSN： 0342-4642 Impact factor: 17.440

23 in total

1. Low-frequency positive-pressure ventilation with extracorporeal CO2 removal in severe acute respiratory failure.

Authors: L Gattinoni; A Pesenti; D Mascheroni; R Marcolin; R Fumagalli; F Rossi; G Iapichino; G Romagnoli; L Uziel; A Agostoni
Journal: JAMA Date: 1986-08-15 Impact factor: 56.272

2. Blood use during extracorporeal membrane oxygenation.

Authors: D McCoy-Pardington; W J Judd; P Knafl; L V Abruzzo; K R Coombes; S H Butch; H A Oberman
Journal: Transfusion Date: 1990-05 Impact factor: 3.157

3. Effect of aprotinin on need for blood transfusion after repeat open-heart surgery.

Authors: D Royston; B P Bidstrup; K M Taylor; R N Sapsford
Journal: Lancet Date: 1987-12-05 Impact factor: 79.321

4. Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass: acquired transient platelet dysfunction associated with selective alpha-granule release.

Authors: L A Harker; T W Malpass; H E Branson; E A Hessel; S J Slichter
Journal: Blood Date: 1980-11 Impact factor: 22.113

5. Reduction of blood transfusion requirement in open heart surgery by administration of high doses of aprotinin--preliminary results.

Authors: G Fraedrich; C Weber; C Bernard; A Hettwer; V Schlosser
Journal: Thorac Cardiovasc Surg Date: 1989-04 Impact factor: 1.827

Review 6. Clinical application of inhibitors of fibrinolysis.

Authors: M Verstraete
Journal: Drugs Date: 1985-03 Impact factor: 9.546

7. Aprotinin protects platelets against the initial effect of cardiopulmonary bypass.

Authors: W van Oeveren; M P Harder; K J Roozendaal; L Eijsman; C R Wildevuur
Journal: J Thorac Cardiovasc Surg Date: 1990-05 Impact factor: 5.209

8. Influence of high-dose aprotinin treatment on blood loss and coagulation patterns in patients undergoing myocardial revascularization.

Authors: W Dietrich; M Spannagl; M Jochum; P Wendt; W Schramm; A Barankay; F Sebening; J A Richter
Journal: Anesthesiology Date: 1990-12 Impact factor: 7.892

9. Plasma kallikrein-kinin system in patients with uncomplicated sepsis and septic shock--comparison with cardiogenic shock.

Authors: F Martínez-Brotóns; J R Oncins; J Mestres; V Amargós; C Reynaldo
Journal: Thromb Haemost Date: 1987-08-04 Impact factor: 5.249