Literature DB >> 12818152

The activation of lymphocytes is in their CARMA.

Abul K Abbas1, Ranjan Sen.   

Abstract

Lymphocyte activation via antigen receptors initiates adaptive immune responses. Two papers in this issue of Immunity demonstrate that CARMA-1, a CARD carrying member of the MAGUK family proteins, is essential for lymphocyte activation. CARMA-1 functions by coupling antigen receptor signals to NF-kappaB induction and JNK activation.

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Year:  2003        PMID： 12818152     DOI： 10.1016/s1074-7613(03)00143-2

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  2 in total

Review 1.  SWAP-70-like adapter of T cells: a novel Lck-regulated guanine nucleotide exchange factor coordinating actin cytoskeleton reorganization and Ca2+ signaling in T cells.

Authors:  Stéphane Bécart; Amnon Altman
Journal:  Immunol Rev       Date:  2009-11       Impact factor: 12.988

2.  Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.

Authors:  Dirk Brenner; Markus Brechmann; Simone Röhling; Myriam Tapernoux; Thomas Mock; Dominic Winter; Wolf D Lehmann; Friedemann Kiefer; Margot Thome; Peter H Krammer; Rüdiger Arnold
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-11       Impact factor: 11.205
  2 in total

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