| Literature DB >> 12817809 |
Masatoshi Taniguchi1, Koji Nagai, Nakako Arao, Tomihisa Kawasaki, Tetsu Saito, Yumiko Moritani, Jun Takasaki, Kazumi Hayashi, Shigeo Fujita, Ken-ichi Suzuki, Shin-ichi Tsukamoto.
Abstract
A novel platelet aggregation inhibitor, YM-254890, was isolated from the culture broth of strain QS3666. This strain was isolated from a soil sample collected at Okutama, Tokyo, Japan, and was identified as Chromobacterium sp. by morphological and physiological criteria. YM-254890 was purified from the culture supernatant by solvent extraction, ODS and silica gel flash chromatography, followed by preparative HPLC. YM-254890 inhibited ADP-induced platelet aggregation in human platelet-rich plasma with an IC50 value below 0.6 microM by blocking the P2Y1 receptor-signal transduction pathway.Entities:
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Year: 2003 PMID： 12817809 DOI： 10.7164/antibiotics.56.358
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649