BACKGROUND AND PURPOSE: We sought to determine the recovery of cortical auditory discrimination in aphasic, left-hemisphere-stroke patients by using an electrophysiological response called mismatch negativity (MMN) and speech-comprehension tests. METHODS: MMN in 8 left-hemisphere stroke patients was recorded in response to duration and frequency changes in a repetitive, harmonically rich tone 4 and 10 days and again 3 and 6 months after their first unilateral stroke. Eight age-matched, healthy persons served as control subjects. RESULTS: At 4 days after stroke onset, patients' sound discrimination was impaired in their left hemisphere, as suggested by attenuated MMNs, especially to right-ear stimuli. At 3 months after stroke, however, MMN to the right-ear duration change had significantly increased and was of normal size. A significant change for the frequency MMN was found for left-ear stimuli between 3 and 6 months after stroke. During the follow-up period, progressive improvement in speech-comprehension tests was also observed. Furthermore, there was a significant correlation between the change in the duration MMN amplitude and the Boston Diagnostic Aphasia Examination speech-comprehension test from 10 days to 3 months after stroke. CONCLUSIONS: These results suggest that the MMN can be used as an index of the recovery of auditory discrimination.
BACKGROUND AND PURPOSE: We sought to determine the recovery of cortical auditory discrimination in aphasic, left-hemisphere-strokepatients by using an electrophysiological response called mismatch negativity (MMN) and speech-comprehension tests. METHODS: MMN in 8 left-hemisphere strokepatients was recorded in response to duration and frequency changes in a repetitive, harmonically rich tone 4 and 10 days and again 3 and 6 months after their first unilateral stroke. Eight age-matched, healthy persons served as control subjects. RESULTS: At 4 days after stroke onset, patients' sound discrimination was impaired in their left hemisphere, as suggested by attenuated MMNs, especially to right-ear stimuli. At 3 months after stroke, however, MMN to the right-ear duration change had significantly increased and was of normal size. A significant change for the frequency MMN was found for left-ear stimuli between 3 and 6 months after stroke. During the follow-up period, progressive improvement in speech-comprehension tests was also observed. Furthermore, there was a significant correlation between the change in the duration MMN amplitude and the Boston Diagnostic Aphasia Examination speech-comprehension test from 10 days to 3 months after stroke. CONCLUSIONS: These results suggest that the MMN can be used as an index of the recovery of auditory discrimination.
Authors: Sundeep Teki; Gareth R Barnes; William D Penny; Paul Iverson; Zoe V J Woodhead; Timothy D Griffiths; Alexander P Leff Journal: Brain Date: 2013-05-28 Impact factor: 13.501
Authors: Bruce I Turetsky; Monica E Calkins; Gregory A Light; Ann Olincy; Allen D Radant; Neal R Swerdlow Journal: Schizophr Bull Date: 2006-11-29 Impact factor: 9.306
Authors: Teppo Särkämö; Mari Tervaniemi; Seppo Soinila; Taina Autti; Heli M Silvennoinen; Matti Laine; Marja Hietanen; Elina Pihko Journal: PLoS One Date: 2010-12-02 Impact factor: 3.240
Authors: Jara Stalpaert; Marijke Miatton; Anne Sieben; Tim Van Langenhove; Pieter van Mierlo; Miet De Letter Journal: Front Hum Neurosci Date: 2021-06-02 Impact factor: 3.169