Literature DB >> 12816485

Synthesis of isochrysohermidin-distamycin hybrids.

Bryan K S Yeung1, Dale L Boger.   

Abstract

The synthesis of the alkylating subunit of the DNA cross-linking agent, isochrysohermidin (2), and its subsequent incorporation into conjugates with distamycin A (1) are described. The DNA binding properties of these agents were compared to that of distamycin A, using a fluorescence intercalator displacement (FID) assay.

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Year:  2003        PMID： 12816485     DOI： 10.1021/jo034326c

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  5 in total

1.  Inverse electron demand Diels-Alder reactions of 1,2,3-triazines: pronounced substituent effects on reactivity and cycloaddition scope.

Authors:  Erin D Anderson; Dale L Boger
Journal:  J Am Chem Soc       Date:  2011-07-19       Impact factor: 15.419

2.  Total synthesis of lycogarubin C and lycogalic acid.

Authors:  James S Oakdale; Dale L Boger
Journal:  Org Lett       Date:  2010-03-05       Impact factor: 6.005

Review 3.  Inverse Electron Demand Diels-Alder Reactions of Heterocyclic Azadienes, 1-Aza-1,3-Butadienes, Cyclopropenone Ketals, and Related Systems. A Retrospective.

Authors:  Jiajun Zhang; Vyom Shukla; Dale L Boger
Journal:  J Org Chem       Date:  2019-05-23       Impact factor: 4.354

4.  A molecular electron density theory study of the participation of tetrazines in aza-Diels-Alder reactions.

Authors:  Luis R Domingo; Mar Ríos-Gutiérrez; Patricia Pérez
Journal:  RSC Adv       Date:  2020-04-21       Impact factor: 4.036

5.  Cycloadditions of noncomplementary substituted 1,2,3-triazines.

Authors:  Erin D Anderson; Adam S Duerfeldt; Kaicheng Zhu; Christopher M Glinkerman; Dale L Boger
Journal:  Org Lett       Date:  2014-09-15       Impact factor: 6.005
  5 in total

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