OBJECTIVE: Patients treated by neuroleptics often develop neuroleptic-induced parkinsonism (NIP) to a varying extent. The reasons for this are discussed controversially in the literature. Previous transcranial sonography (TCS) findings of the substantia nigra (SN) in patients with idiopathic Parkinson's disease suggest a correlation of echogenicity with nigrostriatal dysfunction. METHOD: One hundred psychiatric patients receiving neuroleptics were included. They underwent clinical examination for NIP (Simpson and Angus-scale) and, independently, TCS of the SN. History of smoking habits and medication were taken from the patient's chart. RESULTS: We found a significant positive association of the prevalence of NIP with age (P < 0.01) and the echogenic area of the SN (P < 0.05). Neither type nor dosage of the neuroleptics was found to have any significant impact on the occurrence of NIP. Smokers displayed lower prevalence of NIP (P < 0.05) and lower EPS scores (P < 0.01). CONCLUSIONS: These findings suggest that age and increased size of SN echogenicity are possible risk factors for NIP. In contrast, smoking seems to have a certain protecting effect.
OBJECTIVE:Patients treated by neuroleptics often develop neuroleptic-induced parkinsonism (NIP) to a varying extent. The reasons for this are discussed controversially in the literature. Previous transcranial sonography (TCS) findings of the substantia nigra (SN) in patients with idiopathic Parkinson's disease suggest a correlation of echogenicity with nigrostriatal dysfunction. METHOD: One hundred psychiatricpatients receiving neuroleptics were included. They underwent clinical examination for NIP (Simpson and Angus-scale) and, independently, TCS of the SN. History of smoking habits and medication were taken from the patient's chart. RESULTS: We found a significant positive association of the prevalence of NIP with age (P < 0.01) and the echogenic area of the SN (P < 0.05). Neither type nor dosage of the neuroleptics was found to have any significant impact on the occurrence of NIP. Smokers displayed lower prevalence of NIP (P < 0.05) and lower EPS scores (P < 0.01). CONCLUSIONS: These findings suggest that age and increased size of SN echogenicity are possible risk factors for NIP. In contrast, smoking seems to have a certain protecting effect.
Authors: Mara Balda; Maria Calvó; Eduardo Padilla; Gonzalo Guerrero; Juan Molina; Nestor V Florenzano; Danielle Kamis; Javier I Escobar; C Robert Cloninger; Gabriel de Erausquin Journal: Focus (Am Psychiatr Publ) Date: 2015
Authors: Danielle Kamis; Lee Stratton; María Calvó; Eduardo Padilla; Néstor Florenzano; Gonzalo Guerrero; Beatriz Molina Rangeon; Juan Molina; Gabriel A de Erausquin Journal: Schizophr Res Date: 2015-02-27 Impact factor: 4.939
Authors: Julia Geissler; Thomas Jans; Tobias Banaschewski; Katja Becker; Tobias Renner; Daniel Brandeis; Manfred Döpfner; Christina Dose; Christopher Hautmann; Martin Holtmann; Carolin Jenkner; Sabina Millenet; Marcel Romanos Journal: Trials Date: 2018-04-27 Impact factor: 2.279
Authors: Jose L López-Sendón Moreno; Araceli Alonso-Cánovas; Javier Buisán Catevilla; Nuria García Barragán; Iñigo Corral Corral; Alicia de Felipe Mimbrera; María Consuelo Matute Lozano; Jaime Masjuan Vallejo; Juan Carlos Martínez-Castrillo Journal: Mov Disord Clin Pract Date: 2015-12-18