| Literature DB >> 12814267 |
Anatoly M Vasiliev1, Raisa N Vasilenko, Nataly L Kulikova, Sergey M Andreev, Irina O Chikileva, Galina Yu Puchkova, Igor V Kosarev, Anna V Khodyakova, Valentin S Khlebnikov, Leonid R Ptitsyn, Grygory Ya Shcherbakov, Vladimir N Uversky, Lawrence M DuBuske, Vyacheslav M Abramov.
Abstract
Structural and functional properties of recombinant IL-4delta2, a naturally occurring splice variant of human IL-4 with a deletion of the loop region 22-37, have been analyzed. IL-4delta2 has alpha-helical structure and most likely preserves the "up-up-down-down" topology typical of the four-helix-bundle cytokines. IL-4delta2 interacts specifically with the alpha chain of IL-4R and competes effectively with IL-4 for the common binding sites. Thus, IL-4delta2 may act as a regulator of the cytokine net, being the natural antagonist of IL-4.Entities:
Mesh：
Substances：
Year: 2003 PMID： 12814267 DOI： 10.1021/pr025586y
Source DB: PubMed Journal: J Proteome Res ISSN： 1535-3893 Impact factor: 4.466