| Literature DB >> 12814170 |
G R Davies1, A Ramani, C M Dalton, D J Tozer, C A M Wheeler-Kingshott, G J Barker, A J Thompson, D H Miller, P S Tofts.
Abstract
We report on a new quantitative magnetization transfer (MT) technique that allows for the in vivo estimation of the macromolecular proton fraction (f) and the bound pool T2 relaxation time (T2b), whilst permitting whole brain coverage. In this pilot study, five subjects with multiple sclerosis (MS) and five healthy controls were studied. Both f and T2b were significantly different between MS lesions and normal control white matter (WM). Relationships between f and T1 relaxation time [Spearmans rank correlation coefficient (r(s)) = -0.97, P < 0.001] and f and the magnetization transfer ratio (MTR; r(s) = 0.80, P < 0.001) were observed. Compared with MTR, f and T2b have the potential advantage of relative independence from MT acquisition protocol while offering more pathologically specific information. In particular, f may provide a more direct indication of myelin content in WM.Entities:
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Year: 2003 PMID： 12814170 DOI： 10.1191/1352458503ms911oa
Source DB: PubMed Journal: Mult Scler ISSN： 1352-4585 Impact factor: 6.312