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Literature DB >> 12813015

Arginase: marker, effector, or candidate gene for asthma?

Abstract

Microarray analysis of the expression profiles of lung tissue in two murine models of asthma revealed high levels of arginase I and arginase II activity, in association with IL-4 and IL-13 overexpression, suggesting that arginine pathways are critical in the pathogenesis of asthma.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2003 PMID： 12813015 PMCID： PMC161429 DOI： 10.1172/JCI18908

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

12 in total

1. The involvement of tyrosine kinases, cyclic AMP/protein kinase A, and p38 mitogen-activated protein kinase in IL-13-mediated arginase I induction in macrophages: its implications in IL-13-inhibited nitric oxide production.

Authors: C I Chang; B Zoghi; J C Liao; L Kuo
Journal: J Immunol Date: 2000-08-15 Impact factor: 5.422

Review 2. Regulation of enzymes of the urea cycle and arginine metabolism.

Authors: Sidney M Morris
Journal: Annu Rev Nutr Date: 2002-01-04 Impact factor: 11.848

3. Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene.

Authors: O Shi; S M Morris; H Zoghbi; C W Porter; W E O'Brien
Journal: Mol Cell Biol Date: 2001-02 Impact factor: 4.272

4. A transcriptional corepressor of Stat1 with an essential LXXLL signature motif.

Authors: B Liu; M Gross; J ten Hoeve; K Shuai
Journal: Proc Natl Acad Sci U S A Date: 2001-03-13 Impact factor: 11.205

5. Induction of arginase I and II in bleomycin-induced fibrosis of mouse lung.

Authors: Motoyoshi Endo; Seiichi Oyadomari; Yasuhiro Terasaki; Motohiro Takeya; Moritaka Suga; Masataka Mori; Tomomi Gotoh
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2003-04-04 Impact factor: 5.464

6. Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription.

Authors: K A Mowen; J Tang; W Zhu; B T Schurter; K Shuai; H R Herschman; M David
Journal: Cell Date: 2001-03-09 Impact factor: 41.582

7. IL-4 and IL-13 upregulate arginase I expression by cAMP and JAK/STAT6 pathways in vascular smooth muscle cells.

Authors: L H Wei; A T Jacobs; S M Morris; L J Ignarro
Journal: Am J Physiol Cell Physiol Date: 2000-07 Impact factor: 4.249

8. Exhaled nitric oxide in patients with asthma: association with NOS1 genotype.

Authors: M E Wechsler; H Grasemann; A Deykin; E K Silverman; C N Yandava; E Israel; M Wand; J M Drazen
Journal: Am J Respir Crit Care Med Date: 2000-12 Impact factor: 21.405

9. Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness.

Authors: Herman Meurs; Sue McKay; Harm Maarsingh; Marco A M Hamer; Lejla Macic; Niek Molendijk; Johan Zaagsma
Journal: Br J Pharmacol Date: 2002-06 Impact factor: 8.739

10. Mouse model for human arginase deficiency.

Authors: Ramaswamy K Iyer; Paul K Yoo; Rita M Kern; Nora Rozengurt; Rosemarie Tsoa; William E O'Brien; Hong Yu; Wayne W Grody; Stephen D Cederbaum
Journal: Mol Cell Biol Date: 2002-07 Impact factor: 4.272

26 in total

1. Airway hyperresponsiveness in children with sickle cell anemia.

Authors: Joshua J Field; Janet Stocks; Fenella J Kirkham; Carol L Rosen; Dennis J Dietzen; Trisha Semon; Jane Kirkby; Pamela Bates; Sinziana Seicean; Michael R DeBaun; Susan Redline; Robert C Strunk
Journal: Chest Date: 2010-08-19 Impact factor: 9.410

Review 2. Understanding genomics: implications for the emergency medicine physician and the treatment of asthma.

Authors: Robert J Freishtat; Stephen J Teach
Journal: Pediatr Emerg Care Date: 2006-01 Impact factor: 1.454

3. Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease.

Authors: Nalini Raghavachari; Xiuli Xu; Amy Harris; Jose Villagra; Carolea Logun; Jennifer Barb; Michael A Solomon; Anthony F Suffredini; Robert L Danner; Gregory Kato; Peter J Munson; Sidney M Morris; Mark T Gladwin
Journal: Circulation Date: 2007-03-12 Impact factor: 29.690

Review 4. Nitric oxide metabolism in asthma pathophysiology.

Authors: Sudakshina Ghosh; Serpil C Erzurum
Journal: Biochim Biophys Acta Date: 2011-06-21

5. Parasite-derived arginase influences secondary anti-Leishmania immunity by regulating programmed cell death-1-mediated CD4+ T cell exhaustion.

Authors: Zhirong Mou; Helen M Muleme; Dong Liu; Ping Jia; Ifeoma B Okwor; Shiby M Kuriakose; Stephen M Beverley; Jude E Uzonna
Journal: J Immunol Date: 2013-03-04 Impact factor: 5.422