A paradigm to measure mismatch negativity responses to phonetic and acoustic changes in parallel.

The mismatch negativity (MMN) of the event-related potential has been purported to be an objective index of central auditory processing. The present study tested a new paradigm to measure the MMN responses to phonological changes in parallel with those to simple acoustic changes. Stimulus sequences consisted of repetitive consonant-vowel syllables interspersed with infrequent phonetic changes (in place of articulation or voicing) and repetitive sinusoidal tones with occasional acoustic changes (in frequency or duration). The speech and tone stimuli were delivered to the opposite ears (right and left, respectively) at a stimulus onset asynchrony (SOA) of 300 ms. The MMNs elicited in this new paradigm were compared with those measured in a conventional paradigm, in which the speech and tone stimuli were presented in separate sequences at an identical speech-speech or tone-tone SOA (600 ms) of the new paradigm. The MMNs elicited in the two paradigms had a similar morphology and topography, although the MMNs measured with the new paradigm were slightly smaller for 3 out of 4 types of deviants. The results suggest that the new paradigm enables the measurement of reliable MMNs to phonetic changes in parallel with those to acoustic changes. Copyright 2003 S. Karger AG, Basel