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Literature DB >> 12810806

Autoantibodies to glutamic acid decarboxylase in downbeat nystagmus.

G Antonini¹, R Nemni, F Giubilei, F Gragnani, V Ceschin, S Morino, E Bucci, N Accornero.

Abstract

The cause of downbeat nystagmus (DBN) remains undiagnosed in about 40% of patients. This paper reports the presence of antiglutamic acid decarboxylase antibodies (GAD-Ab) in a patient with DBN. Antibodies against GABAergic neurons located in the vestibular complex may induce chemical denervation of the floccular neurons, which normally suppress the peripheral imbalance between vertical semicircular canal systems, thereby causing DBN. Testing for GAD-Ab may be indicated in DBN patients without an identifiable anatomical brain lesion.

Entities: Chemical Disease Species

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Year: 2003 PMID： 12810806 PMCID： PMC1738554 DOI： 10.1136/jnnp.74.7.998

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

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Cited

14 in total

1. Epilepsy and cerebellar ataxia associated with anti-glutamic acid decarboxylase antibodies.

Authors: S Vulliemoz; G Vanini; A Truffert; C Chizzolini; M Seeck
Journal: J Neurol Neurosurg Psychiatry Date: 2007-02 Impact factor: 10.154

2. New-onset focal epilepsy with palatal tremor and glutamic acid decarboxylase antibodies responding to intravenous immunoglobulin.

Authors: Michael Marnane; Aangela Vincent; Michael Hutchinson
Journal: J Neurol Date: 2008-09-03 Impact factor: 4.849

Autoantibodies to glutamic acid decarboxylase in downbeat nystagmus.

1. Epilepsy and cerebellar ataxia associated with anti-glutamic acid decarboxylase antibodies.

2. New-onset focal epilepsy with palatal tremor and glutamic acid decarboxylase antibodies responding to intravenous immunoglobulin.

3. Epilepsy and cerebellar ataxia associated with anti-glutamic acid decarboxylase antibodies.

Review 4. Localizing forms of nystagmus: symptoms, diagnosis, and treatment.

5. Stiff-Person Syndrome: A Case Report and Review of the Literature.

6. GABA-A receptor impairment in cerebellar ataxia with anti-glutamic acid decarboxylase antibodies.

7. Alternating skew deviation in association with anti-glutamic acid decarboxylase antibodies.

8. Basic and translational neuro-ophthalmology of visually guided saccades: disorders of velocity.

Review 9. Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition.

10. Motor neuronopathy with dropped hands and downbeat nystagmus: a distinctive disorder? A case report.