BACKGROUND: Recently, acute human T-lymphotropic virus type 1-associated myelopathy (HAM) was reported clinically without pathologic information. We report an autopsy case of acute HAM. OBJECTIVE: To report the case of a 52-year-old man with acute-onset gait disturbance followed by rapidly progressive paraplegia, who died 9 months later. RESULTS: The postmortem study showed swelling of the thoracic spinal cord. Histologically, there was inflammation and vacuolation in the white matter. CONCLUSION: We propose that these pathologic findings, mimicking tropical spastic paraparesis, may represent the characteristic pathologic features of acute HAM.
BACKGROUND: Recently, acute human T-lymphotropic virus type 1-associated myelopathy (HAM) was reported clinically without pathologic information. We report an autopsy case of acute HAM. OBJECTIVE: To report the case of a 52-year-old man with acute-onset gait disturbance followed by rapidly progressive paraplegia, who died 9 months later. RESULTS: The postmortem study showed swelling of the thoracic spinal cord. Histologically, there was inflammation and vacuolation in the white matter. CONCLUSION: We propose that these pathologic findings, mimicking tropical spastic paraparesis, may represent the characteristic pathologic features of acute HAM.
Authors: C Griffith; F Bagnato; S Gupta; A Calabrese; U Oh; A Chiu; J M Ohayon; M J McAuliffe; T A Tasciyan; S Jacobson Journal: J Neurovirol Date: 2006-10 Impact factor: 2.643
Authors: Francesca Bagnato; John A Butman; Carlos A Mora; Shiva Gupta; Yoshima Yamano; Talin A Tasciyan; Jeffrey M Solomon; Waldyr J Santos; Roger D Stone; Henry F McFarland; Steven Jacobson Journal: J Neurovirol Date: 2005-12 Impact factor: 2.643
Authors: Felipe von Glehn; Sven Jarius; Augusto C Penalva de Oliveira; Carlos Otávio Brandão; Alessandro S Farias; Alfredo Damasceno; Jorge Casseb; Adriel S Moraes; Ana Leda F Longhini; Klaus-Peter Wandinger; Benito P Damasceno; Brigitte Wildemann; Leonilda M B Santos Journal: PLoS One Date: 2012-07-10 Impact factor: 3.240