Literature DB >> 12810351

Intestinal tissue kallikrein-kallistatin profile in inflammatory bowel disease.

Antoni Stadnicki1, Urszula Mazurek, Danuta Plewka, Tadeusz Wilczok.   

Abstract

The profile of tissue kallikrein (TK) and its inhibitor, kallistatin was evaluated in patients with active ulcerative colitis (UC) and Crohn's disease (CD). Tissue kallikrein is mainly localized to goblet cells and kallistatin to epithelial cells of human intestine. Intestinal tissue kallikrein (ITK) and kallistatin are significantly decreased in inflamed intestine compared to noninflammatory controls. TK mRNA as well as kallistatin mRNA is significantly decreased in intestinal biopsy samples from UC-active patients compared with controls. The difference in distribution and levels of ITK and kallistatin in protein and mRNA in patients with inflammatory bowel disease (IBD) compared to controls suggest a role in inflammatory state.

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Year:  2003        PMID： 12810351     DOI： 10.1016/S1567-5769(03)00054-7

Source DB:  PubMed          Journal:  Int Immunopharmacol        ISSN： 1567-5769            Impact factor:   4.932


  6 in total

Review 1.  Protective Role of Kallistatin in Vascular and Organ Injury.

Authors:  Julie Chao; Grant Bledsoe; Lee Chao
Journal:  Hypertension       Date:  2016-07-18       Impact factor: 10.190

2.  Kallistatin ameliorates influenza virus pathogenesis by inhibition of kallikrein-related peptidase 1-mediated cleavage of viral hemagglutinin.

Authors:  Chia-Hsing Leu; Mei-Lin Yang; Nai-Hui Chung; Yen-Jang Huang; Yu-Chu Su; Yi-Cheng Chen; Chia-Cheng Lin; Gia-Shing Shieh; Meng-Ya Chang; Shainn-Wei Wang; Yao Chang; Julie Chao; Lee Chao; Chao-Liang Wu; Ai-Li Shiau
Journal:  Antimicrob Agents Chemother       Date:  2015-07-06       Impact factor: 5.191

3.  Kallistatin modulates immune cells and confers anti-inflammatory response to protect mice from group A streptococcal infection.

Authors:  Shiou-Ling Lu; Chiau-Yuang Tsai; Yueh-Hsia Luo; Chih-Feng Kuo; Wei-Chieh Lin; Yu-Tzu Chang; Jiunn-Jong Wu; Woei-Jer Chuang; Ching-Chuan Liu; Lee Chao; Julie Chao; Yee-Shin Lin
Journal:  Antimicrob Agents Chemother       Date:  2013-08-19       Impact factor: 5.191

4.  Bradykinin regulates human colonic ion transport in vitro.

Authors:  A W Baird; M M Skelly; D P O'Donoghue; K E Barrett; S J Keely
Journal:  Br J Pharmacol       Date:  2008-07-07       Impact factor: 8.739

5.  Kallistatin exerts anti-lymphangiogenic effects by inhibiting lymphatic endothelial cell proliferation, migration and tube formation.

Authors:  Caiqi Ma; Haofan Yin; Jun Zhong; Yang Zhang; Chuanghua Luo; Di Che; Zhenzhen Fang; Lei Li; Shuxing Qin; Jieying Liang; Weiwei Qi; Zhonghan Yang; Ti Zhou; Jianxing Ma; Xia Yang; Guoquan Gao
Journal:  Int J Oncol       Date:  2017-04-20       Impact factor: 5.650

6.  Plasma kallistatin in critically ill patients with severe sepsis and septic shock.

Authors:  Wei-Chieh Lin; Chang-Wen Chen; Lee Chao; Julie Chao; Yee-Shin Lin
Journal:  PLoS One       Date:  2017-05-24       Impact factor: 3.240
  6 in total

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