| Literature DB >> 12809532 |
Rebecca E Schweppe1, Claire E Haydon, Timothy S Lewis, Katheryn A Resing, Natalie G Ahn.
Abstract
Most biological processes are regulated by post-translational modifications of proteins, and conditions that disrupt the regulation of such events can lead to disease. In the past decade, the identification and characterization of covalent modifications have been driven by advances in mass spectrometry. Here, we discuss current mass spectrometric and proteomic approaches for the identification of proteins and their covalent modifications, and we highlight high-throughput strategies for comprehensive analysis of cell proteomes.Mesh：
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Year: 2003 PMID： 12809532 DOI： 10.1021/ar020143l
Source DB: PubMed Journal: Acc Chem Res ISSN： 0001-4842 Impact factor: 22.384