Literature DB >> 12809363

Bioactive crude plant seed extracts from the NCAUR oilseed repository.

C L Cantrell1, M A Berhow, B S Phillips, S M Duval, D Weisleder, S F Vaughn.   

Abstract

Over four-hundred crude extracts from 202 plant species distributed among 131 plant families were evaluated for their bioactivity against brine shrimp (Artemia salina). Activity was determined for both the organic (CH2Cl2:MeOH) and aqueous extracts against A. salina in a 96 well-plate assay. Of the greater than four-hundred extracts tested, 21 organic and 6 aqueous extracts demonstrated potent cytotoxic activity (LC50 = < 100 microg/ml). Three of these organic extracts (Crateva religiosa, Diospyros dichrophylla, and Olax subscorpioidea) were chosen for chemical investigations due to their high activity and a lack of prior investigations. Chemical analysis of these extracts resulted in the isolation of oleanolic acid (1) and 4-epi-hederagenin (2) from C. religiosa, isodiospyrin (3) from D. dichrophylla, and santalbic acid (4) from O. subscorpioidea.

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Year:  2003        PMID： 12809363     DOI： 10.1078/094471103322004820

Source DB:  PubMed          Journal:  Phytomedicine        ISSN： 0944-7113            Impact factor:   5.340


  8 in total

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Journal:  BMC Complement Med Ther       Date:  2021-09-18

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  8 in total

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