Beneficial effect of coronary artery bypass grafting as assessed by quantitative gated single-photon emission computed tomography.

The development of quantitative gated single-photon emission computed tomography (SPECT) has enabled the assessment of left ventricular perfusion, function and wall thickness in a single examination. Accordingly, the present study used gated SPECT to assess the benefit of coronary artery bypass grafting (CABG) in patients with coronary artery disease; 47 of those patients were evaluated before and 5 months after CABG. As a result of coronary revascularization, a significant improvement was observed in global ejection fraction (50+/-12 --> 53+/-11%; p<0.05). In 107 revascularized territories, the average regional reversible defect score (0.8+/-0.5 --> 0.2 +/-0.3; p<0.0001), average regional perfusion score at rest (0.6+/-0.6 --> 0.3+/-0.4; p<0.0001), average regional wall motion score (0.9+/-0.7 --> 0.7+/-0.5; p<0.05), and end-diastolic wall thickness (8.1+/-1.3 --> 8.6+/-1.5 mm; p<0.0005) all improved significantly. Even in 34 non-revascularized territories, the average regional reversible defect score (0.5+/-0.7 --> 0.2+/-0.5; p<0.03), average regional wall motion score (0.8+/-1.1 --> 0.5 +/-1.0; p<0.03) and end-diastolic wall thickness (8.0+/-1.4 --> 9.1+/-2.0 mm; p<0.03) all improved significantly. These results indicate that improvement in myocardial ischemia, hibernation and left ventricular function with CABG can be assessed in detail with gated SPECT.