| Literature DB >> 12808256 |
Sei-Joon Jeong1, Masanori Inagaki, Ryuichi Higuchi, Tomofumi Miyamoto, Mayumi Ono, Michihiko Kuwano, Rob W M Van Soest.
Abstract
An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner.Entities:
Mesh：
Substances：
Year: 2003 PMID： 12808256 DOI： 10.1248/cpb.51.731
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645