G Winterer1, M-A Enoch, K V White, M Saylan, R Coppola, D Goldman. 1. Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA. wintereg@intra.nimh.nih.gov
Abstract
OBJECTIVE: Electroencephalography (EEG) power and coherence changes may be trait markers for alcoholism providing clues to brain mechanisms of vulnerability. However, it is unclear whether alpha power and coherence differences reflect reversible toxic or withdrawal effects of alcohol. METHOD: The EEGs of 10 non-abstinent and 16 long-term abstinent alcoholics (7.7 +/- 5.8 years) and 25 controls were analyzed. Levels of anxiety and depression were assessed by questionnaire. RESULTS: No statistically significant EEG power differences were observed between groups, although the numerical difference between alcoholics and controls was similar to that previously reported. Bilateral, intrahemispheric, posterior coherences were significantly increased in the alpha and beta frequency bands both in long-term abstinent and non-abstinent alcohol-dependent subjects - particularly when depressiveness was included as a covariate. CONCLUSION: These results suggest that increased EEG-coherence (cortical synchronization) may serve as endophenotype for alcoholism in conjunction with increased depressiveness and point to a possible involvement of GABAergic and/or glutamatergic neurotransmission.
OBJECTIVE: Electroencephalography (EEG) power and coherence changes may be trait markers for alcoholism providing clues to brain mechanisms of vulnerability. However, it is unclear whether alpha power and coherence differences reflect reversible toxic or withdrawal effects of alcohol. METHOD: The EEGs of 10 non-abstinent and 16 long-term abstinent alcoholics (7.7 +/- 5.8 years) and 25 controls were analyzed. Levels of anxiety and depression were assessed by questionnaire. RESULTS: No statistically significant EEG power differences were observed between groups, although the numerical difference between alcoholics and controls was similar to that previously reported. Bilateral, intrahemispheric, posterior coherences were significantly increased in the alpha and beta frequency bands both in long-term abstinent and non-abstinent alcohol-dependent subjects - particularly when depressiveness was included as a covariate. CONCLUSION: These results suggest that increased EEG-coherence (cortical synchronization) may serve as endophenotype for alcoholism in conjunction with increased depressiveness and point to a possible involvement of GABAergic and/or glutamatergic neurotransmission.
Authors: David B Chorlian; Yongqiang Tang; Madhavi Rangaswamy; Sean O'Connor; John Rohrbaugh; Robert Taylor; Bernice Porjesz Journal: Biol Psychol Date: 2007-04-05 Impact factor: 3.251
Authors: Colin A Hodgkinson; Mary-Anne Enoch; Vibhuti Srivastava; Justine S Cummins-Oman; Cherisse Ferrier; Polina Iarikova; Sriram Sankararaman; Goli Yamini; Qiaoping Yuan; Zhifeng Zhou; Bernard Albaugh; Kenneth V White; Pei-Hong Shen; David Goldman Journal: Proc Natl Acad Sci U S A Date: 2010-04-26 Impact factor: 11.205