Literature DB >> 12805843

ASIC3: a lactic acid sensor for cardiac pain.

D C Immke1, E W McCleskey.   

Abstract

Angina, the prototypic vasoocclusive pain, is a radiating chest pain that occurs when heart muscle gets insufficient blood because of coronary artery disease. Other examples of vasoocclusive pain include the acute pain of heart attack and the intermittent pains that accompany sickle cell anemia and peripheral artery disease. All these conditions cause ischemia - insufficient oxygen delivery for local metabolic demand - and this releases lactic acid as cells switch to anaerobic metabolism. Recent discoveries demonstrate that sensory neurons innervating the heart are richly endowed with an ion channel that is opened by, and perfectly tuned for, the lactic acid released by muscle ischemia.

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Year:  2001        PMID： 12805843      PMCID： PMC6084709          DOI： 10.1100/tsw.2001.254

Source DB:  PubMed          Journal:  ScientificWorldJournal        ISSN： 1537-744X


  17 in total

Review 1.  ENaCs and ASICs as therapeutic targets.

Authors:  Yawar J Qadri; Arun K Rooj; Catherine M Fuller
Journal:  Am J Physiol Cell Physiol       Date:  2012-01-25       Impact factor: 4.249

2.  Muscle IL1β Drives Ischemic Myalgia via ASIC3-Mediated Sensory Neuron Sensitization.

Authors:  Jessica L Ross; Luis F Queme; Elysia R Cohen; Kathryn J Green; Peilin Lu; Aaron T Shank; Suzie An; Renita C Hudgins; Michael P Jankowski
Journal:  J Neurosci       Date:  2016-06-29       Impact factor: 6.167

3.  Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration.

Authors:  Niren Kapoor; Rafal Bartoszewski; Yawar J Qadri; Zsuzsanna Bebok; James K Bubien; Catherine M Fuller; Dale J Benos
Journal:  J Biol Chem       Date:  2009-06-26       Impact factor: 5.157

4.  Acid-Sensitive Ion Channels Are Expressed in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Authors:  Xiao-Hua Zhang; Tomo Šarić; Narges Zare Mehrjardi; Sarkawt Hamad; Martin Morad
Journal:  Stem Cells Dev       Date:  2019-06-25       Impact factor: 3.272

5.  Interaction of ASIC1 and ENaC subunits in human glioma cells and rat astrocytes.

Authors:  Niren Kapoor; William Lee; Edlira Clark; Rafal Bartoszewski; Carmel M McNicholas; Cecelia B Latham; Zsuzsanna Bebok; Vladimir Parpura; Catherine M Fuller; Cheryl A Palmer; Dale J Benos
Journal:  Am J Physiol Cell Physiol       Date:  2011-02-23       Impact factor: 4.249

6.  Bioresorbable stents: quo vantis?

Authors:  Nicholas G Kounis; Ioanna Koniari; Periklis Davlouros; George Soufras; Grigorios Tsigkas; George Hahalis
Journal:  J Thorac Dis       Date:  2017-11       Impact factor: 2.895

7.  ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury.

Authors:  Roxanne Y Walder; Lynn A Rasmussen; Jon D Rainier; Alan R Light; John A Wemmie; Kathleen A Sluka
Journal:  J Pain       Date:  2009-12-16       Impact factor: 5.820

Review 8.  Acid-sensing ion channels 3: a potential therapeutic target for pain treatment in arthritis.

Authors:  Feng-Lai Yuan; Fei-Hu Chen; Wei-Guo Lu; Xia Li
Journal:  Mol Biol Rep       Date:  2009-11-03       Impact factor: 2.316

9.  Conformational changes associated with proton-dependent gating of ASIC1a.

Authors:  Christopher J Passero; Sora Okumura; Marcelo D Carattino
Journal:  J Biol Chem       Date:  2009-10-26       Impact factor: 5.157

10.  Dual Modulation of Nociception and Cardiovascular Reflexes during Peripheral Ischemia through P2Y1 Receptor-Dependent Sensitization of Muscle Afferents.

Authors:  Luis F Queme; Jessica L Ross; Peilin Lu; Renita C Hudgins; Michael P Jankowski
Journal:  J Neurosci       Date:  2016-01-06       Impact factor: 6.167
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