BACKGROUND AND PURPOSE: Subarachnoid hemorrhage (SAH) is very difficult to diagnose several months after its onset. We thus investigated subarachnoid hemosiderin deposition well after SAH by T2*-weighted MRI, a sensitive method for hemosiderin detection. METHODS: To investigate how hemosiderin deposition as confirmed by T2*-weighted MRI contributes to the determination of prior SAH and how the extent of hemosiderin deposition is associated with a number of clinical factors, we retrospectively analyzed 58 patients >3 months after SAH associated with ruptured aneurysms. We also investigated 209 healthy volunteers as controls. RESULTS: T2*-weighted MRI demonstrated subarachnoid hemosiderin deposition in 72.4% of the SAH patients, whereas no deposition was seen in the healthy volunteer group. The hemosiderin was preferentially deposited in the subarachnoid space near a ruptured aneurysm. Odds ratios (ORs) were estimated from logistic regression analyses correlating hemosiderin deposition with other factors. Age (>or=54 years) (OR, 5.1; 95% CI, 1.03 to 25.0; P=0.046), Fisher grade 3 on initial CT (OR, 8.0; 95% CI, 1.26 to 50.4; P=0.027), and Karnofsky Scale score <or=80% 6 months after onset of SAH (OR, 12.8; 95% CI, 1.97 to 83.3; P=0.0077) were all found to be independently associated with hemosiderin deposition levels. CONCLUSIONS: T2*-weighted MRI is an effective means of diagnosing prior SAH and may also reveal the location of a ruptured aneurysm. The extent of hemosiderin deposition was significantly associated with several factors, including age, CT findings, and poor prognosis.
BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) is very difficult to diagnose several months after its onset. We thus investigated subarachnoid hemosiderin deposition well after SAH by T2*-weighted MRI, a sensitive method for hemosiderin detection. METHODS: To investigate how hemosiderin deposition as confirmed by T2*-weighted MRI contributes to the determination of prior SAH and how the extent of hemosiderin deposition is associated with a number of clinical factors, we retrospectively analyzed 58 patients >3 months after SAH associated with ruptured aneurysms. We also investigated 209 healthy volunteers as controls. RESULTS: T2*-weighted MRI demonstrated subarachnoid hemosiderin deposition in 72.4% of the SAHpatients, whereas no deposition was seen in the healthy volunteer group. The hemosiderin was preferentially deposited in the subarachnoid space near a ruptured aneurysm. Odds ratios (ORs) were estimated from logistic regression analyses correlating hemosiderin deposition with other factors. Age (>or=54 years) (OR, 5.1; 95% CI, 1.03 to 25.0; P=0.046), Fisher grade 3 on initial CT (OR, 8.0; 95% CI, 1.26 to 50.4; P=0.027), and Karnofsky Scale score <or=80% 6 months after onset of SAH (OR, 12.8; 95% CI, 1.97 to 83.3; P=0.0077) were all found to be independently associated with hemosiderin deposition levels. CONCLUSIONS: T2*-weighted MRI is an effective means of diagnosing prior SAH and may also reveal the location of a ruptured aneurysm. The extent of hemosiderin deposition was significantly associated with several factors, including age, CT findings, and poor prognosis.
Authors: C Jackowski; M Thali; E Aghayev; K Yen; M Sonnenschein; K Zwygart; R Dirnhofer; P Vock Journal: Int J Legal Med Date: 2005-11-19 Impact factor: 2.686
Authors: S Oda; M Shimoda; A Hirayama; M Imai; F Komatsu; H Shigematsu; J Nishiyama; M Matsumae Journal: AJNR Am J Neuroradiol Date: 2015-05-14 Impact factor: 3.825
Authors: J Hodel; R Aboukais; B Dutouquet; E Kalsoum; M A Benadjaoud; D Chechin; M Zins; A Rahmouni; A Luciani; J-P Pruvo; J-P Lejeune; X Leclerc Journal: AJNR Am J Neuroradiol Date: 2014-09-11 Impact factor: 3.825