BACKGROUND AND PURPOSE: Many studies have investigated the association between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and carotid artery intima-media thickness (IMT); however, most studies were small and conducted in selective samples. The aim of this study was to evaluate this association by performing a meta-analysis on published articles. METHODS: We searched Medline for articles studying the association between the ACE I/D polymorphism and carotid IMT. Twenty-six studies were found; 23 articles containing 9833 subjects were qualified to enter the meta-analysis. We classified those articles on the basis of their samples into high-risk and low-risk populations and white and Asian ethnic groups. IMT was used as a continuous variable, and data were analyzed with the Cochrane Review Manager. RESULTS: A significant positive association was present between the D allele and common carotid IMT (weighted mean difference between DD and II genotypes, 0.23 mm x 10(-1); P<0.01). The association was stronger among high-risk populations. The point estimates of DD versus II were higher than those of ID versus II. CONCLUSIONS: Our meta-analysis showed evidence of a positive association between the D allele of the ACE gene and common carotid IMT. The overall results were concordant in both ethnic groups.
BACKGROUND AND PURPOSE: Many studies have investigated the association between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and carotid artery intima-media thickness (IMT); however, most studies were small and conducted in selective samples. The aim of this study was to evaluate this association by performing a meta-analysis on published articles. METHODS: We searched Medline for articles studying the association between the ACE I/D polymorphism and carotid IMT. Twenty-six studies were found; 23 articles containing 9833 subjects were qualified to enter the meta-analysis. We classified those articles on the basis of their samples into high-risk and low-risk populations and white and Asian ethnic groups. IMT was used as a continuous variable, and data were analyzed with the Cochrane Review Manager. RESULTS: A significant positive association was present between the D allele and common carotid IMT (weighted mean difference between DD and II genotypes, 0.23 mm x 10(-1); P<0.01). The association was stronger among high-risk populations. The point estimates of DD versus II were higher than those of ID versus II. CONCLUSIONS: Our meta-analysis showed evidence of a positive association between the D allele of the ACE gene and common carotid IMT. The overall results were concordant in both ethnic groups.
Authors: Yan Meng; Clinton T Baldwin; Abdalla Bowirrat; Kristin Waraska; Rivka Inzelberg; Robert P Friedland; Lindsay A Farrer Journal: Am J Hum Genet Date: 2006-03-16 Impact factor: 11.025
Authors: Jennifer Webster; Eric M Reiman; Victoria L Zismann; Keta D Joshipura; John V Pearson; Diane Hu-Lince; Matthew J Huentelman; David W Craig; Keith D Coon; Thomas Beach; Kristen C Rohrer; Alice S Zhao; Doris Leung; Leslie Bryden; Lauren Marlowe; Mona Kaleem; Diego Mastroeni; Andrew Grover; Joseph Rogers; Reinhard Heun; Frank Jessen; Heike Kölsch; Christopher B Heward; Rivka Ravid; Michael L Hutton; Stacey Melquist; Ron C Petersen; Richard J Caselli; Andreas Papassotiropoulos; Dietrich A Stephan; John Hardy; Amanda Myers Journal: Int J Mol Epidemiol Genet Date: 2009-07-26
Authors: Yi-Chu Liao; Hsiu-Fen Lin; Tatjana Rundek; Rong Cheng; Yuh-Cherng Guo; Ralph L Sacco; Suh-Hang Hank Juo Journal: Stroke Date: 2008-09-11 Impact factor: 7.914
Authors: F A Sayed-Tabatabaei; A F C Schut; A Hofman; A M Bertoli-Avella; J Vergeer; J C M Witteman; C M van Duijn Journal: J Med Genet Date: 2004-02 Impact factor: 6.318