Literature DB >> 12805229

NSD1 is essential for early post-implantation development and has a catalytically active SET domain.

Geetha Vani Rayasam1, Olivia Wendling, Pierre-Olivier Angrand, Manuel Mark, Karen Niederreither, Luyan Song, Thierry Lerouge, Gordon L Hager, Pierre Chambon, Régine Losson.   

Abstract

The nuclear receptor-binding SET domain-containing protein (NSD1) belongs to an emerging family of proteins, which have all been implicated in human malignancy. To gain insight into the biological functions of NSD1, we have generated NSD1-deficient mice by gene disruption. Homozygous mutant NSD1 embryos, which initiate mesoderm formation, display a high incidence of apoptosis and fail to complete gastrulation, indicating that NSD1 is a developmental regulatory protein that exerts function(s) essential for early post-implantation development. We have also examined the enzymatic potential of NSD1 and found that its SET domain possesses intrinsic histone methyltransferase activity with specificity for Lys36 of histone H3 (H3-K36) and Lys20 of histone H4 (H4-K20).

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Year:  2003        PMID： 12805229      PMCID： PMC162140          DOI： 10.1093/emboj/cdg288

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  40 in total

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Review 2.  Coregulator codes of transcriptional regulation by nuclear receptors.

Authors:  M G Rosenfeld; C K Glass
Journal:  J Biol Chem       Date:  2001-07-17       Impact factor: 5.157

Review 3.  Re-SET-ting heterochromatin by histone methyltransferases.

Authors:  T Jenuwein
Journal:  Trends Cell Biol       Date:  2001-06       Impact factor: 20.808

4.  Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression.

Authors:  D O'Carroll; H Scherthan; A H Peters; S Opravil; A R Haynes; G Laible; S Rea; M Schmid; A Lebersorger; M Jerratsch; L Sattler; M G Mattei; P Denny; S D Brown; D Schweizer; T Jenuwein
Journal:  Mol Cell Biol       Date:  2000-12       Impact factor: 4.272

5.  NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines.

Authors:  P O Angrand; F Apiou; A F Stewart; B Dutrillaux; R Losson; P Chambon
Journal:  Genomics       Date:  2001-05-15       Impact factor: 5.736

6.  The polycomb-group gene Ezh2 is required for early mouse development.

Authors:  D O'Carroll; S Erhardt; M Pagani; S C Barton; M A Surani; T Jenuwein
Journal:  Mol Cell Biol       Date:  2001-07       Impact factor: 4.272

7.  A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia.

Authors:  R J Jaju; C Fidler; O A Haas; A J Strickson; F Watkins; K Clark; N C Cross; J F Cheng; P D Aplan; L Kearney; J Boultwood; J S Wainscoat
Journal:  Blood       Date:  2001-08-15       Impact factor: 22.113

8.  Regulation of chromatin structure by site-specific histone H3 methyltransferases.

Authors:  S Rea; F Eisenhaber; D O'Carroll; B D Strahl; Z W Sun; M Schmid; S Opravil; K Mechtler; C P Ponting; C D Allis; T Jenuwein
Journal:  Nature       Date:  2000-08-10       Impact factor: 49.962

9.  Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.

Authors:  A H Peters; D O'Carroll; H Scherthan; K Mechtler; S Sauer; C Schöfer; K Weipoltshammer; M Pagani; M Lachner; A Kohlmaier; S Opravil; M Doyle; M Sibilia; T Jenuwein
Journal:  Cell       Date:  2001-11-02       Impact factor: 41.582

10.  The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts.

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  112 in total

Review 1.  Understanding the language of Lys36 methylation at histone H3.

Authors:  Eric J Wagner; Phillip B Carpenter
Journal:  Nat Rev Mol Cell Biol       Date:  2012-01-23       Impact factor: 94.444

2.  The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation.

Authors:  Qi Qiao; Yan Li; Zhi Chen; Mingzhu Wang; Danny Reinberg; Rui-Ming Xu
Journal:  J Biol Chem       Date:  2010-12-31       Impact factor: 5.157

3.  MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line.

Authors:  Laurel B Bender; Jinkyo Suh; Coleen R Carroll; Youyi Fong; Ian M Fingerman; Scott D Briggs; Ru Cao; Yi Zhang; Valerie Reinke; Susan Strome
Journal:  Development       Date:  2006-10       Impact factor: 6.868

4.  Profile of histone lysine methylation across transcribed mammalian chromatin.

Authors:  Christopher R Vakoc; Mira M Sachdeva; Hongxin Wang; Gerd A Blobel
Journal:  Mol Cell Biol       Date:  2006-10-09       Impact factor: 4.272

5.  Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle.

Authors:  James J Pesavento; Hongbo Yang; Neil L Kelleher; Craig A Mizzen
Journal:  Mol Cell Biol       Date:  2007-10-29       Impact factor: 4.272

Review 6.  Corepressors of agonist-bound nuclear receptors.

Authors:  Igor Gurevich; Anthony M Flores; Brian J Aneskievich
Journal:  Toxicol Appl Pharmacol       Date:  2007-06-14       Impact factor: 4.219

7.  Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila.

Authors:  Oliver Bell; Christiane Wirbelauer; Marc Hild; Annette N D Scharf; Michaela Schwaiger; David M MacAlpine; Frédéric Zilbermann; Fred van Leeuwen; Stephen P Bell; Axel Imhof; Dan Garza; Antoine H F M Peters; Dirk Schübeler
Journal:  EMBO J       Date:  2007-11-15       Impact factor: 11.598

Review 8.  The Role of Nuclear Receptor-Binding SET Domain Family Histone Lysine Methyltransferases in Cancer.

Authors:  Richard L Bennett; Alok Swaroop; Catalina Troche; Jonathan D Licht
Journal:  Cold Spring Harb Perspect Med       Date:  2017-06-01       Impact factor: 6.915

9.  Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma.

Authors:  María Berdasco; Santiago Ropero; Fernando Setien; Mario F Fraga; Pablo Lapunzina; Régine Losson; Miguel Alaminos; Nai-Kong Cheung; Nazneen Rahman; Manel Esteller
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-14       Impact factor: 11.205

10.  Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.

Authors:  Tao Lu; Mark W Jackson; Benlian Wang; Maojing Yang; Mark R Chance; Masaru Miyagi; Andrei V Gudkov; George R Stark
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-22       Impact factor: 11.205
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