Literature DB >> 12804692

FOXP2 in focus: what can genes tell us about speech and language?

Gary F. Marcus1, Simon E. Fisher.   

Abstract

The human capacity for acquiring speech and language must derive, at least in part, from the genome. In 2001, a study described the first case of a gene, FOXP2, which is thought to be implicated in our ability to acquire spoken language. In the present article, we discuss how this gene was discovered, what it might do, how it relates to other genes, and what it could tell us about the nature of speech and language development. We explain how FOXP2 could, without being specific to the brain or to our own species, still provide an invaluable entry-point into understanding the genetic cascades and neural pathways that contribute to our capacity for speech and language.

Entities:  

Year:  2003        PMID: 12804692     DOI: 10.1016/s1364-6613(03)00104-9

Source DB:  PubMed          Journal:  Trends Cogn Sci        ISSN: 1364-6613            Impact factor:   20.229


  27 in total

Review 1.  Animal models of human genetic diseases: do they need to be faithful to be useful?

Authors:  Jean-Louis Guénet
Journal:  Mol Genet Genomics       Date:  2011-05-06       Impact factor: 3.291

2.  FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch.

Authors:  Zachary Daniel Burkett; Nancy F Day; Todd Haswell Kimball; Caitlin M Aamodt; Jonathan B Heston; Austin T Hilliard; Xinshu Xiao; Stephanie A White
Journal:  Elife       Date:  2018-01-23       Impact factor: 8.140

Review 3.  Singing mice, songbirds, and more: models for FOXP2 function and dysfunction in human speech and language.

Authors:  Stephanie A White; Simon E Fisher; Daniel H Geschwind; Constance Scharff; Timothy E Holy
Journal:  J Neurosci       Date:  2006-10-11       Impact factor: 6.167

4.  Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain.

Authors:  Elizabeth Spiteri; Genevieve Konopka; Giovanni Coppola; Jamee Bomar; Michael Oldham; Jing Ou; Sonja C Vernes; Simon E Fisher; Bing Ren; Daniel H Geschwind
Journal:  Am J Hum Genet       Date:  2007-10-31       Impact factor: 11.025

5.  Ultrasonic vocalization impairment of Foxp2 (R552H) knockin mice related to speech-language disorder and abnormality of Purkinje cells.

Authors:  Eriko Fujita; Yuko Tanabe; Akira Shiota; Masatsugu Ueda; Kiyotaka Suwa; Mariko Y Momoi; Takashi Momoi
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-19       Impact factor: 11.205

6.  Language and birdsong: Introduction to the special issue.

Authors:  Eliot A Brenowitz; David J Perkel; Lee Osterhout
Journal:  Brain Lang       Date:  2010-01-12       Impact factor: 2.381

7.  Decoding the molecular evolution of human cognition using comparative genomics.

Authors:  Noriyoshi Usui; Marissa Co; Genevieve Konopka
Journal:  Brain Behav Evol       Date:  2014-09-20       Impact factor: 1.808

Review 8.  Genes and vocal learning.

Authors:  Stephanie A White
Journal:  Brain Lang       Date:  2009-11-13       Impact factor: 2.381

9.  An informatics approach to integrating genetic and neurological data in speech and language neuroscience.

Authors:  Jason W Bohland; Emma M Myers; Esther Kim
Journal:  Neuroinformatics       Date:  2014-01

10.  Generation of mice with a conditional Foxp2 null allele.

Authors:  Catherine A French; Matthias Groszer; Christopher Preece; Anne-Marie Coupe; Klaus Rajewsky; Simon E Fisher
Journal:  Genesis       Date:  2007-07       Impact factor: 2.487

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