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Literature DB >> 12801943

Gut and mind.

Abstract

Obesity is a growing epidemic, causally associated with a number of serious medical conditions, including diabetes mellitus, coronary heart disease, and several cancers. The gut hormones ghrelin and peptide YY are secreted from the gut in response to changes to nutritional status. While food intake is stimulated by ghrelin, it is inhibited by peptide YY. The discovery, anatomy, and physiology of ghrelin and peptide YY are discussed, focusing on the adaptive changes in diseases such as obesity and anorexia nervosa. Ghrelin and PYY are important therapeutic targets in the quest to find an effective antiobesity treatment.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2003 PMID： 12801943 PMCID： PMC1773696 DOI： 10.1136/gut.52.7.918

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

32 in total

1. Long-term follow-up of patients' status after gastric bypass.

Authors: J E Mitchell; K L Lancaster; M A Burgard; L M Howell; D D Krahn; R D Crosby; S A Wonderlich; B A Gosnell
Journal: Obes Surg Date: 2001-08 Impact factor: 4.129

2. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin.

Authors: A Asakawa; A Inui; T Kaga; H Yuzuriha; T Nagata; N Ueno; S Makino; M Fujimiya; A Niijima; M A Fujino; M Kasuga
Journal: Gastroenterology Date: 2001-02 Impact factor: 22.682

Review 3. The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis.

Authors: R D Cone; M A Cowley; A A Butler; W Fan; D L Marks; M J Low
Journal: Int J Obes Relat Metab Disord Date: 2001-12

4. Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression.

Authors: J Kamegai; H Tamura; T Shimizu; S Ishii; H Sugihara; I Wakabayashi
Journal: Endocrinology Date: 2000-12 Impact factor: 4.736

5. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans.

Authors: D E Cummings; J Q Purnell; R S Frayo; K Schmidova; B E Wisse; D S Weigle
Journal: Diabetes Date: 2001-08 Impact factor: 9.461

6. Ghrelin enhances appetite and increases food intake in humans.

Authors: A M Wren; L J Seal; M A Cohen; A E Brynes; G S Frost; K G Murphy; W S Dhillo; M A Ghatei; S R Bloom
Journal: J Clin Endocrinol Metab Date: 2001-12 Impact factor: 5.958

7. Ghrelin causes hyperphagia and obesity in rats.

Authors: A M Wren; C J Small; C R Abbott; W S Dhillo; L J Seal; M A Cohen; R L Batterham; S Taheri; S A Stanley; M A Ghatei; S R Bloom
Journal: Diabetes Date: 2001-11 Impact factor: 9.461

8. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion.

Authors: A M Wren; C J Small; H L Ward; K G Murphy; C L Dakin; S Taheri; A R Kennedy; G H Roberts; D G Morgan; M A Ghatei; S R Bloom
Journal: Endocrinology Date: 2000-11 Impact factor: 4.736

9. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans.

Authors: Y Date; M Kojima; H Hosoda; A Sawaguchi; M S Mondal; T Suganuma; S Matsukura; K Kangawa; M Nakazato
Journal: Endocrinology Date: 2000-11 Impact factor: 4.736

10. Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans.

Authors: H Ariyasu; K Takaya; T Tagami; Y Ogawa; K Hosoda; T Akamizu; M Suda; T Koh; K Natsui; S Toyooka; G Shirakami; T Usui; A Shimatsu; K Doi; H Hosoda; M Kojima; K Kangawa; K Nakao
Journal: J Clin Endocrinol Metab Date: 2001-10 Impact factor: 5.958

11 in total

1. Postprandial ghrelin and PYY responses of male subjects on low carbohydrate meals to varied balancing proportions of proteins and fats.

Authors: Dalia El Khoury; Rola El-Rassi; Sami Azar; Nahla Hwalla
Journal: Eur J Nutr Date: 2010-04-16 Impact factor: 5.614

2. Ghrelin receptor antagonism decreases alcohol consumption and activation of perioculomotor urocortin-containing neurons.

Authors: Simranjit Kaur; Andrey E Ryabinin
Journal: Alcohol Clin Exp Res Date: 2010-06-25 Impact factor: 3.455

3. Relation of fasting plasma peptide YY to glucose metabolism and cardiovascular risk factors after restrictive bariatric surgery.

Authors: Ursula Hanusch-Enserer; Mohammed A Ghatei; Edmund Cauza; Steven R Bloom; Rudolf Prager; Michael Roden
Journal: Wien Klin Wochenschr Date: 2007 Impact factor: 1.704

4. Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).

Authors: B G Challis; A P Coll; G S H Yeo; S B Pinnock; S L Dickson; R R Thresher; J Dixon; D Zahn; J J Rochford; A White; R L Oliver; G Millington; S A Aparicio; W H Colledge; A P Russ; M B Carlton; S O'Rahilly
Journal: Proc Natl Acad Sci U S A Date: 2004-03-15 Impact factor: 11.205

5. Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults.

Authors: Jill A Parnell; Raylene A Reimer
Journal: Am J Clin Nutr Date: 2009-04-22 Impact factor: 7.045

Review 10. The role of "mixed" orexigenic and anorexigenic signals and autoantibodies reacting with appetite-regulating neuropeptides and peptides of the adipose tissue-gut-brain axis: relevance to food intake and nutritional status in patients with anorexia nervosa and bulimia nervosa.

Authors: Kvido Smitka; Hana Papezova; Karel Vondra; Martin Hill; Vojtech Hainer; Jara Nedvidkova
Journal: Int J Endocrinol Date: 2013-09-09 Impact factor: 3.257