Literature DB >> 12801796

GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery?

Paul J Whiting1.   

Abstract

The clinical importance of benzodiazepines, barbiturates and general anesthetics, all of which act through the gamma-aminobutyric acid (GABA)-A neurotransmitter receptor, is testament to its significance as a CNS drug target. These drugs were all developed before there was any understanding of the diversity of this receptor gene family. Recent studies using genetically modified mice and GABA-A receptor-subtype-selective compounds have helped to delineate the function of some of these subtypes, and have revealed that it might be possible to develop a new generation of selective drugs with improved profiles or novel applications.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12801796     DOI： 10.1016/s1359-6446(03)02703-x

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  80 in total

1.  GABA acts as a ligand chaperone in the early secretory pathway to promote cell surface expression of GABAA receptors.

Authors:  Randa S Eshaq; Letha D Stahl; Randolph Stone; Sheryl S Smith; Lucy C Robinson; Nancy J Leidenheimer
Journal:  Brain Res       Date:  2010-05-16       Impact factor: 3.252

Review 2.  Consequences of the evolution of the GABA(A) receptor gene family.

Authors:  Mark G Darlison; Inderjit Pahal; Christian Thode
Journal:  Cell Mol Neurobiol       Date:  2005-06       Impact factor: 5.046

Review 3.  [The GABA(A) receptor family: possibilities for the development of better anesthetics].

Authors:  B Drexler; C Grasshoff; U Rudolph; K Unertl; B Antkowiak
Journal:  Anaesthesist       Date:  2006-03       Impact factor: 1.041

4.  The intronic GABRG2 mutation, IVS6+2T->G, associated with childhood absence epilepsy altered subunit mRNA intron splicing, activated nonsense-mediated decay, and produced a stable truncated γ2 subunit.

Authors:  Mengnan Tian; Robert L Macdonald
Journal:  J Neurosci       Date:  2012-04-25       Impact factor: 6.167

Review 5.  Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection.

Authors:  Jeffrey A Lieberman; Frank P Bymaster; Herbert Y Meltzer; Ariel Y Deutch; Gary E Duncan; Christine E Marx; June R Aprille; Donard S Dwyer; Xin-Min Li; Sahebarao P Mahadik; Ronald S Duman; Joseph H Porter; Josephine S Modica-Napolitano; Samuel S Newton; John G Csernansky
Journal:  Pharmacol Rev       Date:  2008-09       Impact factor: 25.468

Review 6.  GABAA receptor: Positive and negative allosteric modulators.

Authors:  Richard W Olsen
Journal:  Neuropharmacology       Date:  2018-01-31       Impact factor: 5.250

7.  Flurazepam effect on GABAergic currents depends on extracellular pH.

Authors:  T Wójtowicz; P Wyrembek; K Lebida; M Piast; J W Mozrzymas
Journal:  Br J Pharmacol       Date:  2008-03-24       Impact factor: 8.739

Review 8.  GABA(A) receptor and glycine receptor activation by paracrine/autocrine release of endogenous agonists: more than a simple communication pathway.

Authors:  Herve Le-Corronc; Jean-Michel Rigo; Pascal Branchereau; Pascal Legendre
Journal:  Mol Neurobiol       Date:  2011-05-06       Impact factor: 5.590

9.  GABRG1 and GABRA2 as independent predictors for alcoholism in two populations.

Authors:  Mary-Anne Enoch; Colin A Hodgkinson; Qiaoping Yuan; Bernard Albaugh; Matti Virkkunen; David Goldman
Journal:  Neuropsychopharmacology       Date:  2008-09-24       Impact factor: 7.853

10.  Forebrain and midbrain distribution of major benzodiazepine-sensitive GABAA receptor subunits in the adult C57 mouse as assessed with in situ hybridization.

Authors:  S A Heldt; K J Ressler
Journal:  Neuroscience       Date:  2007-09-12       Impact factor: 3.590
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.