Literature DB >> 12801721

An evolutionary approach reveals a high protein-coding capacity of the human genome.

Anton Nekrutenko1, Wen Yu Chung, Wen Hsiung Li.   

Abstract

We developed a new evolutionary method for identifying exons from genomic sequences and found 19000 potential coding exons that are absent from all existing annotations of the human genome. Of these, 13700 satisfied very stringent criteria and can with confidence be considered as novel exons. Evidently, a large number of new human genes can be identified using evolutionary approaches.

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Year:  2003        PMID： 12801721     DOI： 10.1016/S0168-9525(03)00114-8

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  12 in total

1.  Novel RNAs identified from an in-depth analysis of the transcriptome of human chromosomes 21 and 22.

Authors:  Dione Kampa; Jill Cheng; Philipp Kapranov; Mark Yamanaka; Shane Brubaker; Simon Cawley; Jorg Drenkow; Antonio Piccolboni; Stefan Bekiranov; Gregg Helt; Hari Tammana; Thomas R Gingeras
Journal:  Genome Res       Date:  2004-03       Impact factor: 9.043

2.  Identification of novel exons from rat-mouse comparisons.

Authors:  Anton Nekrutenko
Journal:  J Mol Evol       Date:  2004-11       Impact factor: 2.395

3.  Higher intensity of purifying selection on >90% of the human genes revealed by the intrinsic replacement mutation rates.

Authors:  Sankar Subramanian; Sudhir Kumar
Journal:  Mol Biol Evol       Date:  2006-09-18       Impact factor: 16.240

4.  Testing the coding potential of conserved short genomic sequences.

Authors:  Jing Wu
Journal:  Adv Bioinformatics       Date:  2010-03-08

5.  The effects of multiple features of alternatively spliced exons on the K(A)/K(S) ratio test.

Authors:  Feng-Chi Chen; Trees-Juen Chuang
Journal:  BMC Bioinformatics       Date:  2006-05-19       Impact factor: 3.169

6.  Comparative genomics of grass EST libraries reveals previously uncharacterized splicing events in crop plants.

Authors:  Trees-Juen Chuang; Min-Yu Yang; Chuang-Chieh Lin; Ping-Hung Hsieh; Li-Yuan Hung
Journal:  BMC Plant Biol       Date:  2015-02-05       Impact factor: 4.215

7.  The impact of trans-regulation on the evolutionary rates of metazoan proteins.

Authors:  Yi-Ching Chen; Jen-Hao Cheng; Zing Tsung-Yeh Tsai; Huai-Kuang Tsai; Trees-Juen Chuang
Journal:  Nucleic Acids Res       Date:  2013-05-08       Impact factor: 16.971

8.  Improving the specificity of exon prediction using comparative genomics.

Authors:  Jing Wu
Journal:  BMC Genomics       Date:  2008-09-16       Impact factor: 3.969

9.  A novel puf-A gene predicted from evolutionary analysis is involved in the development of eyes and primordial germ-cells.

Authors:  Ming-Wei Kuo; Sheng-Hung Wang; Jui-Chin Chang; Chien-Huei Chang; Ling-Jyun Huang; Hsin-Hung Lin; Alice Lin-Tsing Yu; Wen-Hsiung Li; John Yu
Journal:  PLoS One       Date:  2009-03-25       Impact factor: 3.240

10.  Identification and evolutionary analysis of novel exons and alternative splicing events using cross-species EST-to-genome comparisons in human, mouse and rat.

Authors:  Feng-Chi Chen; Chuang-Jong Chen; Jar-Yi Ho; Trees-Juen Chuang
Journal:  BMC Bioinformatics       Date:  2006-03-15       Impact factor: 3.169
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