| Literature DB >> 12801388 |
Abstract
As our understanding of the complex pathology of Alzheimer's disease improves, more targets for therapy emerge. These include the actions of beta amyloid, the inflammatory cascade, pathobiology of tau proteins' conversion to neurofibrillary tangles, oxidative neuronal damage, and neurotransmitter depletion. Many agents now under investigation target the early stages of the disease process, aiming to prevent or slow the development of symptoms. This article reviews the current understanding of the course and pathology of Alzheimer's disease as it relates to emerging therapies, then summarizes some promising current research directions in primary prevention, secondary prevention, and treatment.Entities:
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Year: 2003 PMID： 12801388 DOI： 10.1046/j.1532-5415.5157.x
Source DB: PubMed Journal: J Am Geriatr Soc ISSN： 0002-8614 Impact factor: 5.562